Please use this identifier to cite or link to this item:
Scopus Web of Science® Altmetric
Type: Journal article
Title: Recurrent Symptoms after Fundoplication with a Negative pH Study--Recurrent Reflux or Functional Heartburn?
Author: Thompson, S.
Cai, W.
Jamieson, G.
Zhang, A.
Myers, J.
Parr, Z.
Watson, D.
Persson, J.
Holtmann, G.
Devitt, P.
Citation: Journal of Gastrointestinal Surgery, 2009; 13(1):54-60
Publisher: Elsevier Svience Inc
Issue Date: 2009
ISSN: 1091-255X
Statement of
Sarah K. Thompson, Wang Cai, Glyn G. Jamieson, Alison Y. Zhang, Jennifer C. Myers, Zoe E. Parr, David I. Watson, Jenny Persson, Gerald Holtmann and Peter G. Devitt
Abstract: Introduction A small cohort of patients present after antireflux surgery complaining of recurrent heartburn. Over two thirds of these patients will have a negative 24-h pH study. The aim of our study is to determine whether these patients have an associated functional disorder or abnormal cytokine activity and to examine the reproducibility of pH testing. Methods A prospective analysis was carried out on a cohort of patients who had undergone a fundoplication and postoperative pH testing for recurrent heartburn: group A—patients with recurrent heartburn and a negative 24-h pH study and group B (control group)—patients with recurrent heartburn and a positive pH study. Questionnaires, a blood sample, and repeat pH testing were completed. Results Sixty-nine patients were identified. Group A’s depression score (8.6 ± 4.1) was significantly higher than group B’s (5.9 ± 4.2; P = 0.03). Cytokine levels were similar in both groups. Forty-seven of 49 (96%) patients who underwent repeat pH testing had a negative study. Symptom-reflux correlation was highly significant (P < 0.001). Conclusion Some patients with recurrent heartburn and a negative pH study have associated functional or psychiatric comorbidities such as depression. Reproducibility of 24-h pH testing in these patients is excellent.
Keywords: Humans
Gastroesophageal Reflux
Postoperative Period
Risk Factors
Follow-Up Studies
Prospective Studies
Hydrogen-Ion Concentration
Middle Aged
Esophageal pH Monitoring
Description: © 2008 The Society for Surgery of the Alimentary Tract
DOI: 10.1007/s11605-008-0653-1
Appears in Collections:Aurora harvest 5
Surgery publications

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.