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Type: Journal article
Title: Important Role for CC Chemokine Ligand 2-Dependent Lung Mononuclear Phagocyte Recruitment to Inhibit Sepsis in Mice Infected with Streptococcus pneumoniae
Author: Winter, C.
Herbold, W.
Maus, R.
Langer, F.
Briles, D.
Paton, J.
Welte, T.
Maus, U.
Citation: Journal of Immunology, 2009; 182(8):4931-4937
Publisher: Amer Assoc Immunologists
Issue Date: 2009
ISSN: 0022-1767
Statement of
Christine Winter, Wiebke Herbold, Regina Maus, Florian Länger, David E. Briles, James C. Paton, Tobias Welte and Ulrich A. Maus
Abstract: The monocyte chemoattractant CCL2 is of major importance in inflammatory monocyte recruitment to the lungs in response to bacterial infection. Streptococcus pneumoniae is the most prevalent pathogen in community-acquired pneumonia causing significant morbidity and mortality worldwide. In the current study, we examined the role of CCL2 in lung-protective immunity against two strains of S. pneumoniae exhibiting different virulence profiles. Both wild-type mice and CCL2 knockout (KO) mice became septic within 24 h of infection with serotype 3 S. pneumoniae and died of infection by day 4 after challenge. In contrast, wild-type mice challenged with serotype 19 S. pneumoniae did not become septic or succumb to pneumococcal pneumonia, whereas CCL2 KO mice showed an early bacterial outgrowth in their lungs and sepsis starting by day 2 after infection, finally resulting in 50% decreased survival compared with wild-type mice. This phenotype was not due to impaired lung neutrophil recruitment in the KO mice, but was characterized by a significantly reduced recruitment of lung exudate macrophages and conventional lung dendritic cells, suggesting that these two phagocyte subsets critically regulate protection against septic disease progression in mice. In conclusion, we show here a differential role for CCL2-dependent lung exudate macrophage and conventional dendritic cell recruitment that critically contributes to lung protective immunity against S. pneumoniae.
Keywords: Dendritic Cells
Mice, Inbred C57BL
Mice, Knockout
Streptococcus pneumoniae
Pneumonia, Pneumococcal
Survival Rate
Chemokine CCL2
Description: Copyright © 2009 by The American Association of Immunologists, Inc.
DOI: 10.4049/jimmunol.0804096
Appears in Collections:Aurora harvest
Molecular and Biomedical Science publications

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