Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/51046
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Type: Journal article
Title: Soy food consumption does not lower LDL cholesterol in either equol or nonequol producers
Author: Thorp, A.
Howe, P.
Mori, T.
Coates, A.
Buckley, J.
Hodgson, J.
Mansour, J.
Meyer, B.
Citation: American Journal of Clinical Nutrition, 2008; 88(2):298-304
Publisher: Amer Soc Clinical Nutrition
Issue Date: 2008
ISSN: 0002-9165
1938-3207
Statement of
Responsibility: 
Alicia A. Thorp, Peter R.C. Howe, Trevor A. Mori, Alison M. Coates, Jonathan D. Buckley, Jonathan Hodgson, Jackie Mansour, and Barbara J. Meyer
Abstract: Health claims link soy protein (SP) consumption, through plasma cholesterol reduction, to a decreased risk of heart disease. Soy isoflavones (ISOs), particularly in individuals who produce equol, might also contribute to lipid lowering and thus reduce SP requirements.The objective was to examine the contributions of SP, ISOs, and equol to the hypocholesterolemic effects of soy foods.Nonsoy consumers (33 men, 58 women) with a plasma total cholesterol (TChol) concentration >5.5 mmol/L participated in a double-blind, placebo-controlled, crossover intervention trial. The subjects consumed 3 diets for 6 wk each in random order, which consisted of foods providing a daily dose of 1) 24 g SP and 70-80 mg ISOs (diet S); 2) 12 g SP, 12 g dairy protein (DP), and 70-80 mg ISOs (diet SD); and 3) 24 g DP without ISOs (diet D). Fasting plasma TChol, LDL cholesterol, HDL cholesterol, and triglycerides (TGs) were measured after each diet.TChol was 3% lower with the S diet (-0.17 +/- 0.06 mmol/L; P < 0.05) than with the D diet, and TGs were 4% lower with both the S (-0.14 +/- 0.05 mmol/L; P < 0.05) and SD (-0.12 +/- 0.05 mmol/L; P < 0.05) diets. There were no significant effects on LDL cholesterol, HDL cholesterol, or the TChol:HDL cholesterol ratio. On the basis of urinary ISOs, 30 subjects were equol producers. Lipids were not affected significantly by equol production.Regular consumption of foods providing 24 g SP/d from ISOs had no significant effect on plasma LDL cholesterol in mildly hypercholesterolemic subjects, regardless of equol-producing status.
Subject: Soyfoods Therapeutic use.
Keywords: Humans
Hypercholesterolemia
Isoflavones
Cholesterol
Triglycerides
Soybean Proteins
Cross-Over Studies
Double-Blind Method
Soy Foods
Adolescent
Adult
Aged
Aged, 80 and over
Middle Aged
Female
Male
Cholesterol, LDL
Cholesterol, HDL
Equol
Biomarkers
Description: © 2008 American Society for Nutrition
DOI: 10.1093/ajcn/88.2.298
Appears in Collections:Aurora harvest
Molecular and Biomedical Science publications

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