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dc.contributor.authorTodd, G.en
dc.contributor.authorRogasch, N.en
dc.contributor.authorFlavel, S.en
dc.contributor.authorRidding, M.en
dc.identifier.citationJournal of Applied Physiology, 2009; 106(5):1593-1603en
dc.description.abstractRepetitive transcranial magnetic stimulation (rTMS) can induce short-term reorganization of human motor cortex. Here, we investigated the effect of rTMS during relaxation and weak voluntary muscle contraction on motor cortex excitability and hand function. Subjects (n = 60) participated in one of four studies. Single transcranial magnetic stimuli were delivered over the motor area of the first dorsal interosseus for measurement of motor evoked potential (MEP) size before and after real or sham rTMS delivered at an intensity of 80% of active motor threshold. rTMS involved trains of stimuli applied at 6 Hz for 5 s and repeated every 30 s for 10 min. Resting MEP size was suppressed for 15 min after rTMS during relaxation. However, MEP suppression was abolished when additional brief voluntary contractions were performed before and after rTMS (study 1). Resting MEP size was suppressed for 30 min after rTMS during weak voluntary contraction. MEP suppression was present even though voluntary contractions were performed before and after rTMS (study 2). The MEP suppression most likely reflects a decrease in motor cortical excitability. Surprisingly, rTMS during voluntary contraction did not alter maximal finger tapping speed or performance on a grooved pegboard test, object grip and lift task (study 3), and visuomotor tracking task (study 4). These studies document the complex relationship between voluntary movement and rTMS-induced plasticity in motor cortex. This work has implications for the optimization of rTMS parameters for improved efficacy and potential therapeutic applications.en
dc.description.statementofresponsibilityGabrielle Todd, Nigel C. Rogasch, Stanley C. Flavel, and Michael C. Riddingen
dc.publisherAmer Physiological Socen
dc.subjectplasticity; motor evoked potential; voluntary muscle contraction; hand functionen
dc.titleVoluntary movement and repetitive transcranial magnetic stimulation over human motor cortexen
dc.typeJournal articleen
pubs.library.collectionMolecular and Biomedical Science publicationsen
dc.identifier.orcidRogasch, N. [0000-0002-4484-1069]en
dc.identifier.orcidRidding, M. [0000-0001-5657-9136]en
Appears in Collections:Molecular and Biomedical Science publications

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