Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/52504
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: Genome analysis of the platypus reveals unique signatures of evolution
Author: Warren, W.
Hillier, L.
Graves, J.
Birney, E.
Ponting, C.
Grutzner, F.
Belov, K.
Miller, W.
Clarke, L.
Chinwall, A.
Yang, S.
Heger, A.
Locke, D.
Miethke, P.
Waters, P.
Veyrunes, F.
Fulton, L.
Fulton, B.
Graves, T.
Wallis, J.
et al.
Citation: Nature, 2008; 453(7192):175-184
Publisher: Nature Publishing Group
Issue Date: 2008
ISSN: 0028-0836
1476-4687
Statement of
Responsibility: 
Wesley C. Warren... Frank Grützner... Enkhjargal Tsend-Ayush... et al.
Abstract: We present a draft genome sequence of the platypus, Ornithorhynchus anatinus. This monotreme exhibits a fascinating combination of reptilian and mammalian characters. For example, platypuses have a coat of fur adapted to an aquatic lifestyle; platypus females lactate, yet lay eggs; and males are equipped with venom similar to that of reptiles. Analysis of the first monotreme genome aligned these features with genetic innovations. We find that reptile and platypus venom proteins have been co-opted independently from the same gene families; milk protein genes are conserved despite platypuses laying eggs; and immune gene family expansions are directly related to platypus biology. Expansions of protein, non-protein-coding RNA and microRNA families, as well as repeat elements, are identified. Sequencing of this genome now provides a valuable resource for deep mammalian comparative analyses, as well as for monotreme biology and conservation.
Keywords: Dentition; Zona Pellucida; Spermatozoa; Venoms; Animals; Mammals; Platypus; Humans; Reptiles; Milk Proteins; Receptors, Odorant; MicroRNAs; Sequence Analysis, DNA; Evolution, Molecular; Phylogeny; Immunity; Genomic Imprinting; Base Composition; Repetitive Sequences, Nucleic Acid; Genome; Female; Male
RMID: 0020080596
DOI: 10.1038/nature06936
Appears in Collections:Molecular and Biomedical Science publications
Environment Institute Leaders publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.