Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/54097
Citations | ||
Scopus | Web of ScienceĀ® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Developing an integrated brain, behavior and biological response profile in posttraumatic stress disorder (PTSD) |
Author: | Falconer, E. Felmingham, K. Allen, A. Clark, C. McFarlane, A. Williams, L. |
Citation: | Journal of Integrative Neuroscience, 2008; 7(3):439-456 |
Publisher: | Inperial College Press |
Issue Date: | 2008 |
ISSN: | 0219-6352 1757-448X |
Statement of Responsibility: | Falconer EM, Felmingham KL, Allen A, Clark CR, McFarlane AC, Williams LM, Bryant RA. |
Abstract: | The present study sought to determine a profile of integrated behavioral, brain and autonomic alterations in PTSD. Previous findings suggest that PTSD is associated with changes across electrophysiological (EEG and ERP), autonomic and cognitive/behavioral measures. In particular, PTSD has been associated with reduced cognitive performance, altered cortical arousal (measured by EEG), diminished late ERP component to oddball task targets (reduced P3 amplitude) and increased autonomic arousal relative to healthy controls. The present study examined measures of cognitive function, auditory oddball ERP components, autonomic function (heart rate and skin conductance) and EEG during resting conditions in 44 individuals with PTSD and 44 non-trauma-exposed controls, and predicted that an integrated profile of changes across a number of these measures would show a high level of sensitivity and specificity in discriminating PTSD from controls. Nine variables showing strongly significant (p < 0.002) between-group differences were entered into a discriminant function analysis. Four of these measures successfully discriminated the PTSD and non-PTSD groups: change in tonic arousal, duration of attention switching, working memory reaction time and errors of commission during visuospatial maze learning. Tonic arousal change contributed the most variance in predicting group membership. These results extend previous findings and provide an integrated biomarker profile that characterizes both PTSD and non-PTSD groups with a high degree of sensitivity and specificity. This outcome provides a platform for future studies to test how this profile of disturbances in autonomic and information processing may be unique to PTSD or may occur generically across clinical and/or other anxiety disorders. |
Keywords: | Brain Autonomic Nervous System Humans Electroencephalography Severity of Illness Index Analysis of Variance Case-Control Studies Behavior Verbal Behavior Mental Processes Cognition Time Perception Arousal Reaction Time Stress Disorders, Post-Traumatic Neuropsychological Tests Adult Middle Aged Female Male |
DOI: | 10.1142/S0219635208001873 |
Description (link): | http://www.ncbi.nlm.nih.gov/pubmed/18988301 |
Published version: | http://dx.doi.org/10.1142/s0219635208001873 |
Appears in Collections: | Aurora harvest Public Health publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.