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https://hdl.handle.net/2440/5471
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Type: | Journal article |
Title: | Neuropeptide release influences brain edema formation after diffuse traumatic brain injury |
Author: | Vink, R. Young, A. Bennett, C. Hu, X. O'Connor, C. Cernak, I. Nimmo, A. |
Citation: | Acta Neurochirurgica: Supplementum, 2003; 86(86):257-260 |
Publisher: | Springer-Verlag Wien |
Issue Date: | 2003 |
ISSN: | 0065-1419 |
Editor: | Kuroiwa, T. Baethmann, A. Czernicki, Z. Hoff, J.T. Ito, U. Katayama, Y. Mararou, A. Mendelow, A.D. Reulen, H.J. |
Abstract: | The mechanisms associated with edema formation after traumatic brain injury (TBI) have not been fully elucidated. In peripheral tissue injury, the neurogenic component of inflammation plays a significant role in increased vascular permeability and edema formation. However, few studies have examined the role of neuropeptide induced neurogenic inflammation following TBI. Adult male Sprague-Dawley rats were either left untreated, or pre-treated with capsaicin (125 mg/kg s.c.) or equal volume vehicle, and injured 14 days later using the 2-meter impact-acceleration model. Subgroups of animals were assessed for blood brain barrier (BBB) permeability (Evans Blue), brain edema (wet weight/dry weight) and functional outcome (Barnes maze and Rotarod) for up to 2 weeks post-trauma. Increased BBB permeability was present in untreated animals between 3 and 6 h after injury but not at later time-points. Edema was maximal at 5 h after trauma, declined and then significantly increased over the 5 days post-trauma. In contrast, capsaicin pre-treated, neuropeptide-depleted animals exhibited no significant increase in BBB permeability or edema compared to vehicle treated animals after injury. Notably, motor and cognitive impairments were significantly reduced in the capsaicin-pretreated animals. We conclude that neurogenic inflammation contributes to the development of edema and posttraumatic deficits after diffuse TBI. |
Keywords: | Blood-Brain Barrier Animals Rats Rats, Sprague-Dawley Brain Edema Brain Injuries Movement Disorders Capsaicin Neuropeptides Motor Activity Cognition Cognition Disorders Capillary Permeability Male |
DOI: | 10.1007/978-3-7091-0651-8_55 |
Published version: | http://dx.doi.org/10.1007/978-3-7091-0651-8_55 |
Appears in Collections: | Aurora harvest Pathology publications |
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