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Type: Journal article
Title: Relations between calcium intake, calcitriol, polymorphisms of the vitamin D receptor gene, and calcium absorption in premenopausal women
Author: Wishart, J.
Horowitz, M.
Need, A.
Scopacasa, F.
Morris, H.
Clifton, P.
Nordin, B.
Citation: American Journal of Clinical Nutrition, 1997; 65(3):798-802
Publisher: American Society for Nutrition
Issue Date: 1997
ISSN: 0002-9165
Statement of
Judith M Wishart, Michael Horowitz, Allan G Need, Franca Scopacasa, Howard A Morris, Peter M Clifton, and B E Christopher Nordin
Abstract: The relations between calcium absorption, dietary calcium intake, 1,25-dihydroxyvitamin D3 (calcitriol), and vitamin D receptor (VDR) gene polymorphisms were evaluated in 99 healthy women who were approaching menopause (mean age: 47 y, range: 43-53 y). Dietary calcium was assessed by food-frequency questionnaire and calcium absorption was measured by a single-isotope radiocalcium test. VDR alleles were classified according to the presence (b, t, a) or absence (B, T, A) of the BsmI, TaqI, and ApaI restriction enzyme cutting sites. Radiocalcium absorption was positively related to serum calcitriol (r = 0.23, P < 0.05) and inversely related to dietary calcium intake (r = -0.26, P < 0.01). There was, however, no significant relation (r = 0.10) between serum calcitriol concentrations and dietary calcium. Radiocalcium absorption was higher in the bbaaTT haplotype (P < 0.05) and the aa genotype (P < 0.05), polymorphisms said to be associated with a higher bone density. We conclude that serum calcitriol and dietary calcium are independent determinants of calcium absorption in premenopausal women and that VDR gene polymorphisms influence calcium absorption.
Keywords: Humans; Calcium, Dietary; Calcitriol; Receptors, Calcitriol; Premenopause; Intestinal Absorption; Genotype; Polymorphism, Genetic; Adult; Middle Aged; Female
Rights: © 1997 American Society for Clinical Nutrition
RMID: 0030006224
DOI: 10.1093/ajcn/65.3.798
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Appears in Collections:Pathology publications

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