Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/55559
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Type: Journal article
Title: Cure of orthopaedic infection with Scedosporium prolificans, using voriconazole plus terbinafine, without the need for radical surgery
Author: Gosbell, I.
Toumasatos, V.
Yong, J.
Kuo, R.
Ellis, D.
Perrie, R.
Citation: Mycoses, 2003; 46(5-6):233-236
Publisher: Blackwell Wissenschafts-Verlag GMBH
Issue Date: 2003
ISSN: 0933-7407
1439-0507
Statement of
Responsibility: 
I. B. Gosbell, V. Toumasatos, J. Yong, R. S. Kuo, D. H. Ellis and R. C. Perrie
Abstract: Scedosporium prolificans infections of normal hosts usually require extensive debridement and sometimes amputation to effect cure, due to the intrinsic resistance of this species to available antifungal agents. Newer agents have not tested favourably. Variable results are obtained with voriconazole, and 100% resistance is described with echinocandins. Itraconazole and terbinafine has offered synergy against various moulds including S. prolificans. In vivo success is reported with the azole/terbinafine combination in S. apiospermum pulmonary infection and Pythium insidiosum periorbital cellulitis. We report a case of orthopaedic infection in a non-immunocompromised host with S. prolificans, in which the combinations of itraconazole/terbinafine and voriconazole/terbinafine showed synergy in vitro, and success was achieved without radical surgery, using voriconazole and terbinafine.
Keywords: Scedosporium prolificans; antimycotic chemotherapy; voriconazole; terbinafine; synergy.
Description: © 2003 Blackwell Publishing Ltd
RMID: 0020091810
DOI: 10.1046/j.1439-0507.2003.00878.x
Appears in Collections:Molecular and Biomedical Science publications

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