Please use this identifier to cite or link to this item:
Scopus Web of ScienceĀ® Altmetric
Type: Journal article
Title: Impact of haemodialysis on individual endogenous plasma acylcarnitine concentrations in end-stage renal disease
Author: Reuter, S.
Evans, A.
Faull, R.
Chace, D.
Fornasini, G.
Citation: Annals of Clinical Biochemistry, 2005; 42(PN Part 5):387-393
Publisher: Royal Soc Medicine Press Ltd
Issue Date: 2005
ISSN: 0004-5632
Statement of
Stephanie E Reuter, Allan M Evans, Randall J Faull, Donald H Chace and Gianfranco Fornasini
Abstract: Background Patients with end-stage renal disease (ESRD) undergoing long-term haemodialysis exhibit low L-carnitine and elevated acylcarnitine concentrations. This study evaluated endogenous concentrations of an array of acylcarnitines (carbon chain length up to 18) in healthy individuals and ESRD patients receiving haemodialysis, and examined the impact of a single haemodialysis session on acylcarnitine concentrations. Methods Blood samples were collected from 60 healthy subjects and 50 ESRD patients undergoing haemodialysis (pre- and post-dialysis samples). Plasma samples were analysed for individual acylcarnitine concentrations by electrospray MS/MS. Results Of the 31 acylcarnitines, 29 were significantly (Po0.05) elevated in ESRD patients compared with healthy controls; in particular, C5 and C8:1 concentrations were substantially elevated. For acylcarnitines with a carbon chain length less than eight, plasma acylcarnitine concentrations decreased significantly over the course of a single dialysis session; however, post-dialysis concentrations invariably remained significantly higher than those in healthy subjects. Dialytic removal of acylcarnitines diminished once the acyl chain length exceeded eight carbons. Conclusions The accumulation of acylcarnitines during long-term haemodialysis suggests that removal by haemodialysis is less efficient than removal from the body by the healthy kidney. Removal is significantly correlated to acyl chain length, most likely due to the increased molecular weight and lipophilicity that accompanies increased chain length.
Keywords: Humans
Kidney Failure, Chronic
Renal Dialysis
Spectrometry, Mass, Electrospray Ionization
Middle Aged
DOI: 10.1258/0004563054889954
Description (link):
Published version:
Appears in Collections:Aurora harvest 5
Pharmacology publications

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.