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https://hdl.handle.net/2440/56704
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Type: | Journal article |
Title: | Outcome following surgery for squamous cell carcinoma of the oesophagus |
Author: | Yong, E. Han, X. Watson, D. Devitt, P. Jamieson, G. Thompson, S. |
Citation: | ANZ Journal of Surgery, 2009; 79(10):724-728 |
Publisher: | Blackwell Science Asia |
Issue Date: | 2009 |
ISSN: | 1445-1433 1445-2197 |
Statement of Responsibility: | En Loon C. Yong, Xing Peng Han, David I. Watson, Peter G. Devitt, Glyn G. Jamieson and Sarah K. Thompson |
Abstract: | <h4>Introduction</h4>This study was undertaken to determine the outcomes of patients treated for squamous cell carcinoma (SCC) of the oesophagus.<h4>Methods</h4>The study group consisted of 61 patients (median age: 64 years) with invasive SCC of the oesophagus who underwent resection between 1987 and 2007 in Adelaide, South Australia. Thirty-two (52%) were female. Survival data were available for all patients. The log rank test was performed to identify prognostic factors for survival.<h4>Results</h4>The 5-year overall survival rate was 33% (median: 24 months). Of 61 patients, 42 (69%) received neoadjuvant therapy prior to surgery. The overall resection rate was 95%. Significant post-operative morbidity occurred in 47%, and the in-hospital mortality was 5% (30-day mortality: 3%). No overall survival benefit was seen in patients undergoing neoadjuvant therapy prior to surgical resection. However, patients who had a complete pathological response to neoadjuvant therapy had a better 5-year survival than patients who did not receive neoadjuvant therapy: 47% versus 30%, respectively.<h4>Conclusions</h4>Oesophagectomy following neoadjuvant therapy for SCC of the oesophagus can be performed with low perioperative mortality. A complete response to neoadjuvant therapy was followed by an improved survival outcome. |
Keywords: | oesophageal cancer oesophagectomy neoadjuvant therapy squamous cell carcinoma |
DOI: | 10.1111/j.1445-2197.2009.05058.x |
Published version: | http://dx.doi.org/10.1111/j.1445-2197.2009.05058.x |
Appears in Collections: | Aurora harvest Surgery publications |
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