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https://hdl.handle.net/2440/58099
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dc.contributor.author | Juhasz, A. | - |
dc.contributor.author | Weber, J. | - |
dc.contributor.author | Smith, E. | - |
dc.contributor.author | Naidu, R. | - |
dc.contributor.author | Marschner, B. | - |
dc.contributor.author | Rees, M. | - |
dc.contributor.author | Rofe, A. | - |
dc.contributor.author | Kuchel, T. | - |
dc.contributor.author | Sansom, L. | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | Environmental Science and Technology (Washington), 2009; 43(12):4503-4509 | - |
dc.identifier.issn | 0013-936X | - |
dc.identifier.issn | 1520-5851 | - |
dc.identifier.uri | http://hdl.handle.net/2440/58099 | - |
dc.description.abstract | In this study, lead (Pb) bioaccessibility in contaminated soils was assessed using an in vitro method (SBRC) encompassing gastric (SBRC-G) and intestinal (SBRC-I) phases. Initially, bioaccessibility studies were performed with a Pb reference material (Pb acetate, 1-10 mg L(-1)) in order to determine the influence of pH on Pb solubility. In the gastric phase (pH 1.5), Pb solubility was 100% (100 +/- 2.9%, n = 16) irrespective of the Pb concentration added, however, when the pH of the intestinal phase was increased to near neutral, Pb solubility decreased to 14.3 +/- 7.2%. In contaminated soils, Pb bioaccessibility varied from 35.7 to 64.1% and 1.2 to 2.7% for SBRC-G and SBRC-I phases, respectively. When relative bioaccessibility (Rel-SBRC-I) was calculated by adjusting the dissolution of Pb from contaminated soils by the solubility of Pb acetate at pH 6.5 (intestinal phase pH); Rel-SBRC-I values ranged from 11.7-26.1%. A stepwise regression model based on Pearson correlation factors was used to determine the suitability of in vitro assays for predicting in vivo (swine assay) relative Pb bioavailability. Rel-SBRC-I provided the best estimate of in vivo relative Pb bioavailability for soils used in this study (in vive relative Pb bioavailability [%] = Rel-SBRC-I [pH 6.5%] x 0.58 + 1.98, P = 0.53). The versatility of Rel-SBRC-I was demonstrated by accurately predicting relative Pb bioavailability from other reported in vivo studies. | - |
dc.description.statementofresponsibility | Albert L. Juhasz, John Weber, Euan Smith, Ravi Naidu, Bernd Marschner, Matthew Rees, Allan Rofe, Tim Kuchel and Lloyd Sansom | - |
dc.language.iso | en | - |
dc.publisher | Amer Chemical Soc | - |
dc.rights | © 2009 American Chemical Society | - |
dc.source.uri | http://dx.doi.org/10.1021/es803238u | - |
dc.subject | Intestinal Mucosa | - |
dc.subject | Gastric Mucosa | - |
dc.subject | Animals | - |
dc.subject | Swine | - |
dc.subject | Lead | - |
dc.subject | Soil Pollutants | - |
dc.subject | Environmental Monitoring | - |
dc.subject | Biological Availability | - |
dc.subject | Models, Biological | - |
dc.subject | Female | - |
dc.title | Evaluation of SBRC-gastric and SBRC-intestinal methods for the prediction of in vivo relative lead bioavailability in contaminated soils | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1021/es803238u | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest Pathology publications |
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