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https://hdl.handle.net/2440/58303
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Type: | Journal article |
Title: | Synthesis and characterization of chitosan/dextran-based hydrogels for surgical use |
Author: | Liu, G. Shi, Z. Kuriger, T. Hanton, L. Simpson, J. Moratti, S. Robinson, B. Athanasiadis, T. Valentine, R. Wormald, P. Robinson, S. |
Citation: | Macromolecular Symposia, 2009; 279(1):151-157 |
Publisher: | Wiley-V C H Verlag GMBH |
Issue Date: | 2009 |
ISSN: | 1022-1360 1521-3900 |
Statement of Responsibility: | G. Liu, Z. Shi, T. Kuriger, L.R. Hanton, J. Simpson, S.C. Moratti, B.H. Robinson, T. Athanasiadis, R. Valentine, P.J. Wormald, S. Robinson |
Abstract: | <jats:title>Abstract</jats:title><jats:p>A series of hydrogels were formed from the reaction between an amine functionalized succinyl chitosan and an oxidized dextran. The properties and rate of formation of the gel were related to both the amine and aldehyde levels of the precursors. These levels could be readily changed by altering the reaction conditions, and allowed good control of the gel properties. Oxidation of the dextran with periodate was accompanied by chain scission and a large reduction in molecular weight. The gel showed excellent haemostatic properties and reduction of adhesions in animal models.</jats:p> |
Keywords: | adhesions chitosan dextran hydrogel imine oxidized periodate succinylation |
Rights: | Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim |
DOI: | 10.1002/masy.200950523 |
Published version: | http://dx.doi.org/10.1002/masy.200950523 |
Appears in Collections: | Aurora harvest Surgery publications |
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