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https://hdl.handle.net/2440/58387
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Type: | Journal article |
Title: | Genetic influences on the pharmacokinetics of orally and intravenously administered Digoxin as exhibited by monozygotic twins |
Author: | Birkenfeld, A. Jordan, J. Hofmann, U. Busjahn, A. Franke, G. Kruger, N. Igel, S. Murdter, T. Drescher, S. Shi, S. Engeli, S. Schwab, M. Eichelbaum, M. Luft, F. Fromm, M. |
Citation: | Clinical Pharmacology and Therapeutics, 2009; 86(6):605-608 |
Publisher: | Mosby Inc |
Issue Date: | 2009 |
ISSN: | 0009-9236 1532-6535 |
Statement of Responsibility: | A. L. Birkenfeld, J. Jordan, U. Hofmann, A. Busjahn, G. Franke, N. Krüger, S. Igel, T. Mürdter, S. Drescher, S. Shi, S. Engeli, M. Schwab, M. Eichelbaum, F. C. Luft and M. F. Fromm |
Abstract: | The expression and function of the drug transporter P-glycoprotein are highly variable. Environmental and genetic factors contribute to this variation. We studied the disposition of digoxin, a frequently used probe drug for P-glycoprotein function in humans, in monozygotic (MZ) twins and found that digoxin pharmacokinetics after oral and intravenous administration are highly correlated within MZ twins, supporting the hypothesis of a robust contribution from genetic variance. Our study suggests that studies involving twins could be more widely applied to elucidate pharmacogenetics. |
Keywords: | Humans Deuterium Digoxin Administration, Oral Infusions, Intravenous Registries Pilot Projects Twins, Monozygotic Genotype Phenotype Adult Female Male Genetic Variation Young Adult ATP Binding Cassette Transporter, Subfamily B ATP Binding Cassette Transporter, Subfamily B, Member 1 |
Rights: | Copyright © 2009, Nature Publishing Group |
DOI: | 10.1038/clpt.2009.170 |
Published version: | http://dx.doi.org/10.1038/clpt.2009.170 |
Appears in Collections: | Aurora harvest Pharmacology publications |
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