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Type: Journal article
Title: Proton-pump inhibitors and the risk of antibiotic use and hospitalisation for pneumonia
Author: Roughead, E.
Ramsay, E.
Pratt, N.
Ryan, P.
Gilbert, A.
Citation: Medical Journal of Australia, 2009; 190(3):114-116
Publisher: Australasian Med Publ Co Ltd
Issue Date: 2009
ISSN: 0025-729X
Statement of
Elizabeth E Roughead, Emmae N Ramsay, Nicole L Pratt, Philip Ryan and Andrew L Gilbert
Abstract: Objective: To determine whether proton-pump inhibitor (PPI) use is associated with hospitalisations for pneumonia and with antibiotic use. Design and setting: Historical cohort study in the Australian veteran population, conducted from 1 January 2002 to 30 December 2006, comparing veterans exposed to PPIs with those not exposed. Participants: All 185 533 veterans who were Gold Card holders (ie, eligible for all health services subsidised by the Department of Veterans’ Affairs) and aged 65 years and over at 1 January 2002 and had been prescribed at least one medicine in the previous 6 months. Main outcome measures: The primary endpoint was hospitalisation for pneumonia. Secondary endpoints included hospitalisation for bacterial pneumonia and dispensings of antibiotics commonly used to treat respiratory tract infections. Results: After adjustment for potential confounders, we found an increased risk of hospitalisation for pneumonia among those exposed to PPIs compared with the unexposed group (rate ratio [RR], 1.16; 95% CI, 1.11–1.22). The risk was not increased for bacterial pneumonia (RR, 1.13; 95% CI, 0.98–1.31), which made up 8% of pneumonia cases. An increased risk of antibiotic dispensings was observed among those exposed to PPIs (RR, 1.23; 95% CI, 1.21–1.24). Conclusions: PPI dispensings were found to be associated with a small but significant increased risk of hospitalisation for pneumonia. While the increased risk is small, the prevalent use of PPIs means that many people could be affected.
Keywords: Humans
Pneumonia, Bacterial
Anti-Bacterial Agents
Confidence Intervals
Risk Assessment
Risk Factors
Cohort Studies
Veterans Disability Claims
Drug Utilization
Proton Pump Inhibitors
Rights: © The Medical Journal of Australia 2009
DOI: 10.5694/j.1326-5377.2009.tb02307.x
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