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Type: Journal article
Title: DNA repair gene polymorphisms and prostate cancer risk in South Australia-results of a pilot study
Author: Dhillon, Varinderpal
Yeoh, Eng Kiat
Fenech, Michael Felix
Citation: Urologic Oncology, 2011; 29(6):641–646
Publisher: Elsevier
Issue Date: 2011
ISSN: 1078-1439
School/Discipline: School of Medical Sciences : Pharmacology
Statement of
Varinderpal S. Dhillon M., Eric Yeoh and Michael Fenech
Abstract: Objective: Single nucleotide polymorphisms (SNPs) in DNA repair genes may impact on DNA damage, and cancer risk. To elucidate the role of SNPs in DNA repair genes in prostate cancer (PC) we conducted a case-control study comprising of 118 Caucasian men affected with late onset PC and 132 age-matched healthy controls from South Australia. Methods and materials: We examined the association between PC risk with nonsynonymous SNPs (nsSNPs) in 5 genes involved in 3 DNA-repair pathways: (1) base excision repair (BER): hOGG1 C1245G (Ser326Cys) and XRCC1 G28152A (Arg399Gln); (2) nucleotide excision repair (NER): XPD G23591A (Asp312Asn); (3) homologous recombination repair: RAD51 G135C (in 5′ untranslated region) and XRCC3 C18067T (Thr241Met). Results: Prostate cancer risk was significantly increased only for carriers of the G allele of the C1245G polymorphism in the hOGG1 gene (OR = 2.28; 95% CI = 1.36–3.83; P = 0.002). Conclusion: Our results suggest that this common nsSNP in a gene involved in repair of oxidative damage to DNA may contribute to PC susceptibility in South Australian men.
Keywords: Prostate cancer; DNA repair genes; polymorphisms
Rights: © 2009 Elsevier Inc. All rights reserved.
DOI: 10.1016/j.urolonc.2009.08.013
Appears in Collections:Pharmacology publications

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