Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/5904
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Type: | Journal article |
Title: | Muscle weakness after muscle relaxants: An audit of clinical practice |
Author: | Alkhazrajy, W. Khorasanee, A. Russell, W. |
Citation: | Anaesthesia and Intensive Care, 2004; 32(2):256-259 |
Publisher: | Australian Soc Anaesthetists |
Issue Date: | 2004 |
ISSN: | 0310-057X 1448-0271 |
Abstract: | Residual muscle weakness after general anaesthesia, assessed using handgrip strength, was audited in a teaching hospital. The relationships between residual weakness, the use of muscle relaxants and patient characteristics were examined. Handgrip strength was measured preoperatively, one hour postoperatively and one day postoperatively using a hand dynamometer in 151 patients having general anaesthesia. Forty-nine patients received no muscle relaxant, 34 patients received vecuronium and 68 received rocuronium. Patients were managed by their anaesthetist according to that anaesthetist’s clinical choice. All patients who received muscle relaxants received neostigmine. One hour postoperatively, there was a decline in handgrip strength of 16% for the no relaxant group, 24% for vecuronium and 29% for rocuronium. The degree of weakness for the relaxant groups was unrelated to age (P=0.89) but was strongly influenced by the patient’s sex. Almost all of the increased weakness with relaxants was found in the female patients. The mean decline in handgrip strength in the male patients who received either vecuronium or rocuronium was similar to that seen when relaxants had not been used (P=0.40). One hour postoperatively, female patients showed a marked decrease in handgrip strength after both vecuronium and rocuronium (32% and 34% respectively, combined P=0.01). These results suggest that in usual clinical practice at our institution, female patients are more likely to have residual weakness after muscle relaxants. |
Keywords: | Humans Muscle Weakness Neostigmine Androstanols Vecuronium Bromide Cholinesterase Inhibitors Neuromuscular Nondepolarizing Agents Hand Strength Anesthesia, General Postoperative Period Risk Age Factors Sex Factors Time Factors Medical Audit Female Male Rocuronium |
Description: | Publisher's copy made available with the permission of the publisher © Australian Society of Anaesthetists |
DOI: | 10.1177/0310057x0403200216 |
Description (link): | http://www.aaic.net.au/Article.asp?D=2003117 |
Published version: | http://dx.doi.org/10.1177/0310057x0403200216 |
Appears in Collections: | Anaesthesia and Intensive Care publications Aurora harvest |
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