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Type: Journal article
Title: The influence of the bolus injection rate of propofol on its cardiovascular effects and peak blood concentrations in sheep
Author: Zheng, D.
Upton, R.
Martinez, A.
Grant, C.
Ludbrook, G.
Citation: Anesthesia and Analgesia, 1998; 86(5):1109-1115
Publisher: International Anesthesia Research Society
Issue Date: 1998
ISSN: 0003-2999
Statement of
Da Zheng, Richard N. Upton, Allison M. Martinez, Cliff Grant, and Guy L. Ludbrook
Abstract: <h4>Unlabelled</h4>The influence of the bolus injection rate of propofol on its cardiovascular effects has not been extensively studied. We therefore examined the influence of the injection rate of i.v. bolus doses of propofol on its acute cardiovascular effects and peak blood concentrations in seven chronically instrumented sheep. Each received i.v. propofol (200 mg) over 2 min (slow injection) and 0.5 min (rapid injection) on separate occasions in random order. The rapid injection was associated with more profound decreases in mean arterial blood pressure than slow injection (35.7% vs 23.7% maximal reductions from baseline, respectively; P = 0.02). There were no significant differences between the injection rates for peak reductions in myocardial contractility, increases in heart rate, or degree of respiratory depression. Concurrently, the rapid injections were associated with significantly higher arterial (26.9 vs 11.9 mg/L) propofol concentrations in a manner consistent with indicator dilution principles. There were no differences in the peak coronary sinus concentrations between the injection rates. We conclude that the rapid injection of propofol in the context of the induction of anesthesia produced significantly higher peak arterial propofol concentrations and suggest that it is these higher concentrations that produced relatively greater reductions in arterial blood pressure from rapid injections.<h4>Implications</h4>Propofol is injected into a vein to initiate anesthesia. It can cause a rapid decrease in blood pressure, which may be dangerous to the patient. We examined the effect of rapid and slow injection rates of propofol in sheep and found that rapid injection caused a greater decrease in blood pressure. This was because rapid injection caused higher concentrations of propofol in the blood immediately after the injection. We believe that if the same processes occur in humans, there may be little advantage in injecting propofol rapidly.
Keywords: Animals
Anesthetics, Intravenous
Injections, Intravenous
Oxygen Consumption
Blood Pressure
Coronary Circulation
Description: Copyright © 1998 by International Anesthesia Research Society
DOI: 10.1097/00000539-199805000-00039
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Appears in Collections:Anaesthesia and Intensive Care publications
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