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https://hdl.handle.net/2440/5983
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DC Field | Value | Language |
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dc.contributor.author | Ong, J. | - |
dc.contributor.author | Kerr, D. | - |
dc.contributor.author | Bowden, J. | - |
dc.contributor.author | Prager, R. | - |
dc.date.issued | 1999 | - |
dc.identifier.citation | European Journal of Pharmacology, 1999; 367(2-3):207-211 | - |
dc.identifier.issn | 0014-2999 | - |
dc.identifier.issn | 1879-0712 | - |
dc.identifier.uri | http://hdl.handle.net/2440/5983 | - |
dc.description.abstract | Cholinergic twitch responses in the guinea-pig isolated ileum, and spontaneous discharges in rat neocortical slices, were depressed by the GABA(B) receptor agonist baclofen. These actions were reversibly antagonised by the sulphonamide derivatives (R,S)-2-hydroxy-3-phthalimidopropanesulphonamide (HPIPS), 3-amino-N-benzoylpropanesulphonamide (ABPS) and 3-phthalimidopropanesulphonamide (PIPS) which produced rightwards shifts of the baclofen concentration-response curves, with pA2 values ranging between 4.1 and 4.3 in both preparations. From these results, HPIPS, ABPS and PIPS constitute a novel class of antagonists at GABA(B) hetero-receptors. | - |
dc.language.iso | en | - |
dc.publisher | Elsevier BV | - |
dc.source.uri | http://dx.doi.org/10.1016/s0014-2999(98)00962-5 | - |
dc.subject | Muscle, Smooth | - |
dc.subject | Ileum | - |
dc.subject | Neocortex | - |
dc.subject | Animals | - |
dc.subject | Guinea Pigs | - |
dc.subject | Rats | - |
dc.subject | Rats, Sprague-Dawley | - |
dc.subject | Sulfonamides | - |
dc.subject | gamma-Aminobutyric Acid | - |
dc.subject | Baclofen | - |
dc.subject | GABA Agonists | - |
dc.subject | GABA Antagonists | - |
dc.subject | Drug Interactions | - |
dc.subject | Male | - |
dc.subject | GABA-B Receptor Antagonists | - |
dc.subject | In Vitro Techniques | - |
dc.title | Evaluation of 3-aminopropanesulphonamide analogues of GABA as antagonists at GABA (B) receptors in peripheral and central preparations | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/S0014-2999(98)00962-5 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Ong, J. [0000-0002-0958-460X] | - |
Appears in Collections: | Anaesthesia and Intensive Care publications Aurora harvest 5 |
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