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Results 21-30 of 37 (Search time: 0.006 seconds).
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Issue Date
Title
Author(s)
2010
The poor response to imatinib observed in CML patients with low OCT-1 activity is not attributable to lower uptake of imatinib into their CD34⁺ cells
Engler, J.
;
Frede, A.
;
Saunders, V.
;
Zannettino, A.
;
White, D.
;
Hughes, T.
2005
In vitro sensitivity to imatinib-induced inhibition of ABL kinase activity is predictive of molecular response in patients with de-novo CML.
White, D.
;
Saunders, V.
;
Lyons, A.
;
Branford, S.
;
Grigg, A.
;
To, L.
;
Hughes, T.
2006
OCT-1-mediated influx is a key determinant of the intraceflular uptake of imatinib but not nilotinib, (AMN107): reduced OCT-1 activity is the cause of low in vitro sensitivity to imatinib
White, D.
;
Saunders, V.
;
Dang, P.
;
Engler, J.
;
Zannettino, A.
;
Cambareri, A.
;
Quinn, S.
;
Manley, P.
;
Hughes, T.
2010
Plasma adiponectin levels are markedly elevated in imatinib-treated chronic myeloid leukemia (CML) patients: A mechanism for improved insulin sensitivity in Type 2 diabetic CML patients?
Fitter, S.
;
Vandyke, K.
;
Schultz, C.
;
White, D.
;
Hughes, T.
;
Zannettino, A.
2012
Classification of patients with chronic myeloid leukemia on basis of BCR-ABL transcript level at 3 months fails to identify patients with low organic cation transporter-1 activity destined to have poor imatinib response
White, D.
;
Hughes, T.
2007
Most CML patients who have a suboptimal response to imatinib have low OCT-1 activity: higher doses of imatinib may overcome the negative impact of low OCT-1 activity
White, D.
;
Saunders, V.
;
Dang, P.
;
Engler, J.
;
Venables, A.
;
Zrim, S.
;
Zannettino, A.
;
Lynch, K.
;
Manley, P.
;
Hughes, T.
2007
Imatinib increases the intracellular concentration of nilotinib which may explain the observed synergy between these drugs
White, D.
;
Saunders, V.
;
Quinn, S.
;
Manley, P.
;
Hughes, T.
2010
Functional activity of the OCT-1 protein is predictive of long-term outcome in patients with chronic-phase chronic myeloid leukemia treated with Imatinib
White, D.
;
Dang, P.
;
Engler, J.
;
Frede, A.
;
Osborn, M.
;
Saunders, V.
;
Manley, P.
;
Zrim, S.
;
Hughes, T.
2007
Measurement of in vivo BCR-ABL kinase inhibition to monitor imatinib-induced target blockade and predict response in chronic myeloid leukemia
White, D.
;
Saunders, V.
;
Grigg, A.
;
Arthur, C.
;
Filshie, R.
;
Leahy, M.
;
Lynch, K.
;
To, L.
;
Hughes, T.
2011
SHP-1 expression accounts for resistance to imatinib treatment in Philadelphia chromosome-positive cells derived from patients with chronic myeloid leukemia
Esposito, N.
;
Colavita, I.
;
Quintarelli, C.
;
Sica, A.
;
Peluso, A.
;
Luciano, L.
;
Picardi, M.
;
Vecchio, L.
;
Buonomo, T.
;
Hughes, T.
;
White, D.
;
Radich, J.
;
Russo, D.
;
Branford, S.
;
Saglio, G.
;
Vaz de Melo, J.
;
Martinelli, R.
;
Ruoppolo, M.
;
Kalebic, T.
;
Martinelli, G.
;
et al.
Discover
Author
12
Saunders, V.
6
Dang, P.
6
Hiwase, D.
6
To, L.
5
Branford, S.
5
Engler, J.
4
Eadie, L.
4
Grigg, A.
4
Kok, C.
4
Leclercq, T.
.
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Subject
28
Leukemia, Myelogenous, Chronic, B...
25
Pyrimidines
20
Imatinib Mesylate
18
Piperazines
17
Antineoplastic Agents
17
Benzamides
14
Male
14
Protein Kinase Inhibitors
13
Female
12
Adult
.
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Date issued
25
2010 - 2018
10
2000 - 2009
2
1995 - 1999