Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/62953
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: The poor response to imatinib observed in CML patients with low OCT-1 activity is not attributable to lower uptake of imatinib into their CD34⁺ cells
Other Titles: The poor response to imatinib observed in CML patients with low OCT-1 activity is not attributable to lower uptake of imatinib into their CD34(+) cells
Author: Engler, J.
Frede, A.
Saunders, V.
Zannettino, A.
White, D.
Hughes, T.
Citation: Blood, 2010; 116(15):2776-2778
Publisher: Amer Soc Hematology
Issue Date: 2010
ISSN: 0006-4971
1528-0020
Statement of
Responsibility: 
Jane R. Engler, Amity Frede, Verity Saunders, Andrew Zannettino, Deborah L. White, and Timothy P. Hughes
Abstract: The functional activity of the organic cation transporter 1 (OCT-1) protein in chronic myeloid leukemia (CML) mononuclear cells (MNCs) is highly predictive of molecular response in imatinib treated patients. Here we investigate whether the MNC OCT-1 activity (OA) provides a surrogate indicator of effective targeting of the more immature CD34(+) cells. While confirming our previous findings that high MNC OA is significantly associated with the achievement of major molecular response (MMR; P = .017), the present studies found no relationship between high CD34(+) OA and the achievement of MMR. Furthermore, no correlation was found between the MNC OA and the CD34(+) OA in matched CML samples. These results suggest that the predictive value of the MNC OA may primarily reflect the effective targeting and subsequent reduction of mature CML cells. Therefore kinase inhibition in these mature cells, and not the CD34(+) cells, may be the key determinant of response in CML.
Keywords: Leukocytes, Mononuclear; Myeloid Progenitor Cells; Humans; Piperazines; Pyrimidines; Organic Cation Transporter 1; Antineoplastic Agents; Antigens, CD34; Prognosis; Treatment Outcome; Neoplastic Stem Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Rights: © 2010 by The American Society of Hematology
RMID: 0020101115
DOI: 10.1182/blood-2010-01-267013
Appears in Collections:Medicine publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.