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Type: Journal article
Title: Famciclovir for the treatment of acute herpes zoster: Effects on acute disease and post-herpetic neuralgia
Author: Tyring, S.
Barbarash, R.
Nahlik, J.
Cunningham, A.
Marley, J.
Heng, M.
Jones, T.
Rea, T.
Boon, R.
Saltzman, R.
Citation: Annals of Internal Medicine, 1995; 123(2):89-96
Publisher: Annuals of Internal Medicine
Issue Date: 1995
ISSN: 0003-4819
Statement of
Stephen Tyring; Rick A. Barbarash; James E. Nahlik; Anthony Cunningham; John Marley; Madalene Heng; Terry Jones; Ted Rea; Ron Boon; Robin Saltzman, The Collaborative Famciclovir Herpes Zoster Study Group
Abstract: <h4>Objective</h4>To document the effects of treatment with famciclovir on the acute signs and symptoms of herpes zoster and postherpetic neuralgia.<h4>Design</h4>A randomized, double-blind, placebo-controlled, multicenter trial.<h4>Setting</h4>36 centers in the United States, Canada, and Australia.<h4>Patients</h4>419 immunocompetent adults with uncomplicated herpes zoster.<h4>Intervention</h4>Patients were assigned within 72 hours of rash onset to famciclovir, 500 mg; famciclovir, 750 mg; or placebo, three times daily for 7 days.<h4>Measurements</h4>Lesions were assessed daily for as long as 14 days until full crusting occurred and then weekly until the lesions healed. Viral cultures were obtained daily while vesicles were present. Pain was assessed at each of the visits at which lesions were examined and then monthly for 5 months after the lesions healed. Safety was assessed throughout the study.<h4>Results</h4>Famciclovir was well tolerated, with a safety profile similar to that of placebo. Famciclovir accelerated lesion healing and reduced the duration of viral shedding. Most importantly, famciclovir recipients had faster resolution of postherpetic neuralgia (approximately twofold faster) than placebo recipients; differences between the placebo group and both the 500-mg famciclovir group (hazard ratio, 1.7 [95% CI, 1.1 to 2.7]) and the 750-mg famciclovir group (hazard ratio, 1.9 [CI, 1.2 to 2.9]) were statistically significant (P = 0.02 and 0.01, respectively). The median duration of postherpetic neuralgia was reduced by approximately 2 months.<h4>Conclusions</h4>Oral famciclovir, 500 mg or 750 mg three times daily for 7 days, is an effective and well-tolerated therapy for herpes zoster that decreases the duration of the disease's most debilitating complication, postherpetic neuralgia.
Keywords: Humans
Herpesvirus 3, Human
Herpes Zoster
Acute Disease
Antiviral Agents
Patient Compliance
Virus Shedding
Time Factors
Middle Aged
DOI: 10.7326/0003-4819-123-2-199507150-00002
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