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https://hdl.handle.net/2440/61353
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dc.contributor.author | Karnon, J. | - |
dc.contributor.author | Holmes, M. | - |
dc.contributor.author | Williams, R. | - |
dc.contributor.author | Bakhai, A. | - |
dc.contributor.author | Brennan, A. | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | International Journal of Cardiology, 2010; 140(3):315-322 | - |
dc.identifier.issn | 0167-5273 | - |
dc.identifier.issn | 1874-1754 | - |
dc.identifier.uri | http://hdl.handle.net/2440/61353 | - |
dc.description.abstract | Design: Cost utility analysis using a cohort Markov model, incorporating clinical data from two pivotal clinical trials (the COMMIT/CCS-2 and CLARITY-TIMI 28 trials) and data from UK and non-UK observational studies. Setting: Health economic evaluation carried out from the perspective of the UK NHS. Patients: A representative cohort of 1000 UK patients aged 60 years, diagnosed with STEMI. Interventions: 75 mg/day clopidogrel, with and without a 300 mg loading dose, in addition to standard therapy (including aspirin, 75–325 mg/day) for 1 month, and for 1 year, followed by standard therapy alone for their remaining lifetime, or standard therapy alone (including aspirin, 75–325 mg/day) for their remaining lifetime. Main outcome measures: Incremental cost per quality-adjusted life-year (QALY) gained (ICER). Results: For the 1-month treatment option both the COMMIT/CCS-2 and CLARITY-TIMI 28 trials have ICERs below £2500. For the 1-year treatment option both trials have ICERs below £4000. Extensive univariate and probabilistic sensitivity analyses showed these results to be robust. Conclusions: In combination with previous economic analyses of clopidogrel in NSTEMI patients, this paper demonstrates that clopidogrel appears to offer a cost-effective treatment option for all ACS patients. | - |
dc.description.statementofresponsibility | Jonathan Karnon, Mike W. Holmes, Robert Williams, Ameet Bakhai, Alan Brennan | - |
dc.language.iso | en | - |
dc.publisher | Elsevier Sci Ireland Ltd | - |
dc.rights | Copyright © 2008 Elsevier Ireland Ltd. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1016/j.ijcard.2008.11.105 | - |
dc.subject | ST elevation acute myocardial infarction (STEMI) | - |
dc.subject | Aspirin, Clopidogrel | - |
dc.subject | Cost effectiveness | - |
dc.subject | Markov model | - |
dc.subject | QALYs | - |
dc.title | A cost-utility analysis of clopidogrel in patients with ST elevation acute coronary syndromes in the UK | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.ijcard.2008.11.105 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Karnon, J. [0000-0003-3220-2099] | - |
Appears in Collections: | Aurora harvest 5 Public Health publications |
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