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https://hdl.handle.net/2440/61467
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Type: | Journal article |
Title: | Treatment of ocular surface squamous neoplasia with Mitomycin C |
Author: | Gupta, A. Muecke, J. |
Citation: | British Journal of Ophthalmology, 2010; 94(5):555-558 |
Publisher: | British Med Journal Publ Group |
Issue Date: | 2010 |
ISSN: | 0007-1161 1468-2079 |
Statement of Responsibility: | A. Gupta and J. Muecke |
Abstract: | Aim: To report the outcome of treatment of non-invasive ocular surface squamous neoplasia (or conjunctivalcorneal intra-epithelial neoplasia (CCIN)) where topical mitomycin C (MMC) has been used in the treatment regimen. Design: Prospective, non-comparative interventional case series. Participants: 91 primary or recurrent CCIN lesions from 90 patients treated in a single ocular oncology centre over a 10.5-year period. Intervention 73 cases of localised, non-invasive CCIN and eight cases of recurrent CCIN received a treatment regimen of surgical excision6cryotherapy, followed by two to three 1-week cycles of adjuvant topical MMC (0.04% four times a day). 10 cases of diffuse CCIN received two to three 1-week cycles of topical MMC (0.04% four times a day) as sole primary treatment. Main outcome measure: Successful treatment was defined as no clinical recurrence of CCIN. Results: Mean follow-up of 56.8 months (range 5.8 to 119.8) and median 57.3 months, revealed no recurrences (0%) in the localised primary group, and one persistent case and two recurrences (30%) in the diffuse primary group. There was one recurrence (12.5%) in the recurrent group, but this was in the only eye with a diffuse type of recurrence. Conclusions: MMC treatment following surgical excision appears to decrease the recurrence rate of localised CCIN and should be considered as adjuvant therapy in primary treatment. MMC should also be considered as adjuvant therapy in the treatment of localised recurrent disease. MMC may be used as sole therapy in more diffuse disease, but close ongoing follow-up is recommended in view of the significant risk of persistent or recurrent disease. |
Keywords: | Humans Carcinoma in Situ Eye Neoplasms Conjunctival Neoplasms Neoplasm Recurrence, Local Corneal Diseases Mitomycin Antibiotics, Antineoplastic Treatment Outcome Chemotherapy, Adjuvant Follow-Up Studies Prospective Studies Adult Aged Aged, 80 and over Middle Aged Female Male |
Rights: | Copyright © The Authors |
DOI: | 10.1136/bjo.2009.168294 |
Published version: | http://dx.doi.org/10.1136/bjo.2009.168294 |
Appears in Collections: | Aurora harvest Opthalmology & Visual Sciences publications |
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hdl_61467.pdf | Published version | 85.91 kB | Adobe PDF | View/Open |
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