Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/61531
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dc.contributor.author | Brooks, A. | - |
dc.contributor.author | Stiles, M. | - |
dc.contributor.author | Laborderie, J. | - |
dc.contributor.author | Lau, D. | - |
dc.contributor.author | Kuklik, P. | - |
dc.contributor.author | Shipp, N. | - |
dc.contributor.author | Hsu, L. | - |
dc.contributor.author | Sanders, P. | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | Heart Rhythm, 2010; 7(6):835-846 | - |
dc.identifier.issn | 1547-5271 | - |
dc.identifier.issn | 1556-3871 | - |
dc.identifier.uri | http://hdl.handle.net/2440/61531 | - |
dc.description.abstract | <h4>Background</h4>Ablation of long-standing persistent atrial fibrillation (AF) is highly variable, with differing techniques and outcomes.<h4>Objective</h4>The purpose of this study was to undertake a systematic review of the literature with regard to the impact of ablation technique on the outcomes of long-standing persistent AF ablation.<h4>Methods</h4>A systematic search of the contemporary English scientific literature (from January 1, 1990 to June 1, 2009) in the PubMed database identified 32 studies on persistent/long-standing persistent or long-standing persistent AF ablation (including four randomized controlled trials). Data on single-procedure, drug-free success, multiple procedure success, and pharmaceutically assisted success at longest follow-up were collated.<h4>Results</h4>Four studies performed pulmonary vein isolation alone (21%-22% success). Four studies performed pulmonary vein antrum ablation with isolation (PVAI; n = 2; 38%-40% success) or without confirmed isolation (PVA; n = 2; 37%-56% success). Ten studies performed linear ablation in addition to PVA (n = 5; 11%-74% success) or PVAI (n = 5; 38%-57% success). Three studies performed posterior wall box isolation (n = 3; 44%-50% success). Five studies performed complex fractionated atrial electrogram ablation (n = 5; 24%-63% success). Six studies performed complex fractionated atrial electrogram ablation as an adjunct to PVA (n = 2; 50%-51% success), PVAI (n = 3; 36%-61% success), or PVAI and linear (n = 1; 68% success) ablation. Five studies performed the stepwise ablation approach (38%-62% success).<h4>Conclusion</h4>The variation in success within and between techniques suggests that the optimal ablation technique for long-standing persistent AF is unclear. Nevertheless, long-standing persistent AF can be effectively treated with a composite of extensive index catheter ablation, repeat procedures, and/or pharmaceuticals. | - |
dc.description.statementofresponsibility | Anthony G. Brooks, Martin K. Stiles, Julien Laborderie, Dennis H. Lau, Pawel Kuklik, Nicholas J. Shipp, Li-Fern Hsu, and Prashanthan Sanders | - |
dc.description.uri | http://www.elsevier.com/wps/find/journaldescription.cws_home/702333/description#description | - |
dc.language.iso | en | - |
dc.publisher | Elsevier Inc. | - |
dc.relation.isreplacedby | 2440/90210 | - |
dc.relation.isreplacedby | http://hdl.handle.net/2440/90210 | - |
dc.rights | © 2010 Heart Rhythm Society. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1016/j.hrthm.2010.01.017 | - |
dc.subject | Ablation | - |
dc.subject | Atrial fibrillation | - |
dc.subject | Systematic review | - |
dc.subject | Long-standing persistent atrial fibrillation | - |
dc.title | Outcomes of long-standing persistent atrial fibrillation ablation: A systematic review | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.hrthm.2010.01.017 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Lau, D. [0000-0001-7753-1318] | - |
dc.identifier.orcid | Kuklik, P. [0000-0001-8440-654X] | - |
dc.identifier.orcid | Sanders, P. [0000-0003-3803-8429] | - |
Appears in Collections: | Aurora harvest 2 Molecular and Biomedical Science publications |
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hdl_61531.pdf | Accepted version | 2.05 MB | Adobe PDF | View/Open |
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