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Type: Journal article
Title: Warfarin Indications, risks and drug interactions
Author: Tadros, R.
Shakib, S.
Citation: Australian Family Physician, 2010; 39(7):476-479
Publisher: Royal Australian College of General Practitioners
Issue Date: 2010
ISSN: 0300-8495
Statement of
Rami Tadros and Sepehr Shakib
Abstract: Background: Warfarin is a commonly used medication for the prevention and treatment of venous thromboembolism. It can be challenging for both the patient and the prescriber to manage at times. Objective: To describe the mechanism of action of warfarin, and to discuss the indications for warfarinisation, the risks associated with warfarin use, and some of its drug interactions. Discussion: The common indications for warfarinisation are atrial fibrillation, venous thromboembolism and prosthetic heart valves. Contraindications include absolute and relative contraindications, and an individualised risk-benefit analyses is required for each patient. There are many interactions with warfarin, including pharmacokinetic and pharmacodynamic. Pharmacokinetic interactions can be monitored by using International Normalised Ratio levels. Pharmacodynamic interactions require knowledge by the prescriber to predict any interactions with warfarin, and International Normalised Ratio monitoring assists.
Keywords: warfarin
International Normalised Ratio
atrial fibrillation
venous thromboembolism
heart valve prosthesis
Rights: Copyright status unknown
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Appears in Collections:Aurora harvest
Pharmacology publications

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