Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/6213
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Type: | Journal article |
Title: | Hyponatraemia and hypokalaemia due to indapamide |
Author: | Chapman, M. Hanrahan, R. McEwen, J. Marley, J. |
Citation: | Medical Journal of Australia, 2002; 176(5):219-221 |
Publisher: | Australasian Med Publ Co Ltd |
Issue Date: | 2002 |
ISSN: | 0025-729X 1326-5377 |
Statement of Responsibility: | Michael D Chapman, Ross Hanrahan, John McEwen and John E Marley |
Abstract: | Objectives: To review Australian adverse drug reaction reports describing hyponatraemia and hypokalaemia attributed to indapamide and compare the characteristics of the patients with those in Australian reports implicating two other diuretic products (hydrochlorothiazide and amiloride hydrochloride; chlorothiazide). Design: Descriptive analysis using reports from the database of the Adverse Drug Reactions Advisory Committee (ADRAC). Main outcome measures: Numbers of reports of hyponatraemia and hypokalaemia; proportion of such reports in total reports of adverse reactions to each drug; severity of electrolyte disturbances. Results: Between August 1984 and September 2000, 84 Australian reports of hyponatraemia and 87 reports of hypokalaemia, in which indapamide was the sole suspected drug, were submitted to ADRAC. Most reports involved an indapamide dose of 2.5 mg daily. There was a significantly greater proportion of reports of hyponatraemia with indapamide and with the hydrochlorothiazide and amiloride combination than with chlorothiazide; hypokalaemia was significantly more common for indapamide than for the other two drugs. Of the 87 reports of hypokalaemia with indapamide, 35 patients also had hyponatraemia. For all three drugs, at least 80% of reports of hyponatraemia were in people aged 65 or over, and electrolyte disturbance was most commonly reported in elderly women. Conclusions: Hyponatraemia and hypokalaemia have been described in 20.9% and 21.7%, respectively, of reports to ADRAC in which indapamide was the sole suspected drug. The electrolyte disturbances can be severe. |
Keywords: | Humans Hypokalemia Hyponatremia Indapamide Amiloride Chlorothiazide Hydrochlorothiazide Diuretics Drug Combinations Drug Utilization Australia Sodium Chloride Symporter Inhibitors |
Description: | The document attached has been archived with permission from the editor of the Medical Journal of Australia (10 January 2008). An external link to the publisher’s copy is included. |
DOI: | 10.5694/j.1326-5377.2002.tb04377.x |
Published version: | http://www.mja.com.au/public/issues/176_05_040302/cha10368.html |
Appears in Collections: | Aurora harvest General Practice publications |
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hdl_6213.pdf | Published version | 145.12 kB | Adobe PDF | View/Open |
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