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Type: Book chapter
Title: Mast cells and immunoregulation/immunomodulation
Author: Tsai, M.
Grimbaldeston, M.
Galli, S.
Citation: Mast Cell Biology: Contemporary and Emerging Topics, 2011 / Gilfillan, A., Metcalfe, D. (ed./s), vol.716, pp.186-211
Part of: Advances in Experimental Medicine and Biology
Publisher: Springer
Publisher Place: 233 Spring St New York NY 10013
Issue Date: 2011
ISBN: 9781441995322
Editor: Gilfillan, A.
Metcalfe, D.
Statement of
Mindy Tsai, Michele Grimbaldeston and Stephen J. Galli
Abstract: Mast cells often represent one of the first cells of the immune system to interact with environmental antigens, invading pathogens or environmentally-derived toxins. Mast cells also can undergo alterations in phenotype, anatomic distribution and numbers during innate or adaptive immune responses. In addition to their well-known roles as effector cells during IgE- and antigen-induced allergic reactions, mast cells can be activated by many other signals, including some that are derived directly from pathogens or which are generated during innate or adaptive immune responses. Mast cells also express many costimulatory molecules with immunoregulatory activities and can secrete many products that can positively or negatively regulate immune responses. In this chapter, we describe mouse models used for analyzing mast-cell function in vivo and illustrate how such models have been used to identify positive or negative immunomodulatory roles for mast cells during specific innate or adaptive immune responses. We also briefly describe some of the mast-cell functions, products and surface receptors that have the potential to permit mast cells to promote or suppress immune responses that can either enhance host defense or contribute to disease.
Keywords: Mast Cells
Rights: © Springer, Part of Springer Science+Business Media
DOI: 10.1007/978-1-4419-9533-9_11
Appears in Collections:Aurora harvest 5
Molecular and Biomedical Science publications

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