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https://hdl.handle.net/2440/67127
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dc.contributor.author | Sandow, J. | - |
dc.contributor.author | Jabbour, A. | - |
dc.contributor.author | Condina, M. | - |
dc.contributor.author | Daunt, C. | - |
dc.contributor.author | Stomski, F. | - |
dc.contributor.author | Green, B. | - |
dc.contributor.author | Riffkin, C. | - |
dc.contributor.author | Hoffmann, P. | - |
dc.contributor.author | Guthridge, M. | - |
dc.contributor.author | Silke, J. | - |
dc.contributor.author | Lopez, A. | - |
dc.contributor.author | Ekert, P. | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Cell Death and Differentiation, 2012; 19(4):633-641 | - |
dc.identifier.issn | 1350-9047 | - |
dc.identifier.issn | 1476-5403 | - |
dc.identifier.uri | http://hdl.handle.net/2440/67127 | - |
dc.description.abstract | P53-upregulated modifier of apoptosis (PUMA), a pro-apoptotic member of the Bcl-2 family, is transcriptionally activated by p53 and is a key effector of p53-dependent apoptosis. We show that PUMA protein is subject to rapid post-translational regulation by phosphorylation at a conserved residue, serine 10, following serum or interleukin-3 (IL-3) stimulation. Serine 10 is not within the Bcl-2 homology (BH3) domain, and PUMA phosphorylated at serine 10 retained the ability to co-immunoprecipitate with antiapoptotic Bcl-2 family members. However, phosphorylated PUMA was targeted for proteasomal degradation indicating that it is less stable than unphosphorylated PUMA. Importantly, we identified IKK1/IKK2/Nemo as the kinase complex that interacts with and phosphorylates PUMA, thereby also demonstrating that IL-3 activates NFκB signaling. The identification and characterization of this novel survival pathway has important implications for IL-3 signaling and hematopoietic cell development. | - |
dc.description.statementofresponsibility | JJ Sandow, AM Jabbour, MR Condina, CP Daunt, FC Stomski, BD Green, CD Riffkin, P Hoffmann, MA Guthridge, J Silke, AF Lopez and PG Ekert | - |
dc.language.iso | en | - |
dc.publisher | Nature Publishing Group | - |
dc.rights | Copyright 2011 Macmillan Publishers Limited | - |
dc.source.uri | http://dx.doi.org/10.1038/cdd.2011.131 | - |
dc.subject | PUMA | - |
dc.subject | interleukin-3 | - |
dc.subject | post-translational | - |
dc.subject | phosphorylation | - |
dc.subject | degradation | - |
dc.subject | IKK | - |
dc.title | Cytokine receptor signaling activates an IKK-dependent phosphorylation of PUMA to prevent cell death | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1038/cdd.2011.131 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Lopez, A. [0000-0001-7430-0135] | - |
Appears in Collections: | Aurora harvest 5 IPAS publications |
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