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Type: Journal article
Title: Effect of sex on symptoms associated with gastroesophageal reflux
Author: Chen, Z.
Thompson, S.
Jamieson, G.
Devitt, P.
Watson, D.
Citation: Archives of Surgery, 2011; 146(10):1164-1169
Publisher: Amer Medical Assoc
Issue Date: 2011
ISSN: 0004-0010
Statement of
Zhen Chen, Sarah K. Thompson, Glyn G. Jamieson, Peter G. Devitt, David I. Watson
Abstract: Background: Previous research suggests that females have a poorer outcome than do males after surgery for gastroesophageal reflux. Objective: To evaluate reflux and esophageal symptoms in males and females in a community sample and in patients undergoing antireflux surgery. Design: Face-to-face interview. Setting: A South Australian community. Participants: Random sample of 2973 individuals from the community and 2153 patients presenting for antireflux surgery. Main Outcome Measures: In a random sample of 2973 individuals from the community, the prevalence of reflux and other esophageal symptoms was determined and compared with symptoms in 2153 patients presenting for antireflux surgery. Identical questions were used to assess frequency and severity of heartburn and dysphagia and medication use. Analog scales assessed heartburn and dysphagia (0 indicating no symptoms and 10, severe symptoms). Outcomes for males vs females were compared across both groups. Results: In the community, females were more likely to report heartburn, and when reported, symptom severity was higher. The prevalence of dysphagia was similar for males and females, although females reported higher dysphagia scores for solid foods. A similar proportion of males and females took antireflux medications. Females presenting for antireflux surgery were, on average, 7 years older than males, had a higher body mass index, and had higher heartburn and dysphagia symptom scores. At endoscopy, men were more likely to have ulcerative esophagitis and Barrett esophagus, and at surgery they were less likely to have a hiatal hernia. Conclusions: Significant differences were noted between males and females in the frequency and severity of gastroesophageal reflux–associated symptoms in the community and in patients presenting for surgery. These might reflect differences in symptom perception, which explain previously reported better outcomes in men undergoing antireflux surgery.
Keywords: Humans
Deglutition Disorders
Gastroesophageal Reflux
Severity of Illness Index
Cohort Studies
Sex Factors
Aged, 80 and over
Middle Aged
South Australia
Young Adult
Rights: ©2011 American Medical Association. All rights reserved.
DOI: 10.1001/archsurg.2011.248
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Appears in Collections:Aurora harvest 5
Surgery publications

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