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Type: Journal article
Title: An unusual kynurenine-containing opioid tetrapeptide from the skin gland secretion of the Australian red tree frog Litoria rubella. Sequence determination by electrospray mass spectrometry
Author: Ellis-Steinborner, S.
Scanlon, D.
Musgrave, I.
Tran, T.
Hack, S.
Wang, T.
Abell, A.
Tyler, M.
Bowie, J.
Citation: Rapid Communications in Mass Spectrometry, 2011; 25(12):1735-1740
Publisher: John Wiley & Sons Ltd
Issue Date: 2011
ISSN: 0951-4198
Statement of
Simon T. Ellis‐Steinborner, Denis Scanlon, Ian F. Musgrave, T. T. Nha Tran, Sandra Hack, Tianfang Wang, Andrew D. Abell, Michael J. Tyler and John H. Bowie
Abstract: The Kyn-containing peptide FP-Kyn-L(NH(2)) is an unusual minor component of the skin peptide profile of the Australian red tree frog Litoria rubella collected from an area within a 20 kilometre radius of Alice Springs in central Australia. The structure was determined by electrospray mass spectrometry and synthesis. The major component of the skin secretion is the analogous tryptophyllin peptide FPWL(NH(2)). Both peptides show opioid activity at 10(-7) M, and are likely to act via the μ opioid receptor.
Keywords: Skin; Animals; Anura; Kynurenine; Oligopeptides; Receptors, Opioid; Analgesics, Opioid; Spectrometry, Mass, Electrospray Ionization; Sequence Analysis, Protein; Australia
Rights: Copyright © 2011 John Wiley & Sons, Ltd.
RMID: 0020110785
DOI: 10.1002/rcm.5041
Appears in Collections:IPAS publications

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