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dc.contributor.authorYelland, L.en
dc.contributor.authorSalter, A.en
dc.contributor.authorRyan, P.en
dc.identifier.citationThe International Journal of Biostatistics, 2011; 7(1):2-33en
dc.description.abstractThe relative risk is a clinically important measure of the effect of treatment on binary outcomes in randomized controlled trials (RCTs). An adjusted relative risk can be estimated using log binomial regression; however, convergence problems are common with this model. While alternative methods have been proposed for estimating relative risks, comparisons between methods have been limited, particularly in the context of RCTs. We compare ten different methods for estimating relative risks under a variety of scenarios relevant to RCTs with independent observations. Results of a large simulation study show that some methods may fail to overcome the convergence problems of log binomial regression, while others may substantially overestimate the treatment effect or produce inaccurate confidence intervals. Further, conclusions about the effectiveness of treatment may differ depending on the method used. We give recommendations for choosing a method for estimating relative risks in the context of RCTs with independent observations.en
dc.description.statementofresponsibilityLisa N. Yelland, Amy B. Salter, and Philip Ryanen
dc.publisherBerkeley Electronic Pressen
dc.rights©2011 Berkeley Electronic Press. All rights reserved.en
dc.subjectbinary outcome; log binomial regression; randomized controlled trial; relative risk; simulationen
dc.titleRelative risk estimation in randomized controlled trials: A comparison of methods for independent observationsen
dc.typeJournal articleen
pubs.library.collectionPublic Health publicationsen
dc.identifier.orcidYelland, L. [0000-0003-3803-8728]en
Appears in Collections:Public Health publications

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