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Type: Conference item
Title: DNA detection using molecular beacon in soft-glass microstructured optical fibers
Author: Nguyen, L.
Warren-Smith, S.
Cooper, A.
Monro, T.
Citation: 22nd International Conference on Optical Fiber Sensors, Beijing, China, 2012: 4p.
Issue Date: 2012
Series/Report no.: Proceedings of SPIE
ISBN: 9780819491039
ISSN: 0277-786X
Conference Name: International Conference on Optical Fiber Sensors (22nd : 2012 : Beijing, China)
Editor: Liao, Y.
Jin, W.
Sampson, D.D.
Yamauchi, R.
Chung, Y.
Nakamura, K.
Rao, Y.
Statement of
Linh Viet Nguyen, Stephen C. Warren-Smith, Alan Cooper, Tanya M. Monro
Abstract: We report, for the first time to our knowledge, the detection of specific strands of DNA based on a soft-glass microstructured optical fiber (MOF) platform loaded with molecular beacons (MBs). This detection scheme brings together the intrinsic advantage of MOF for low-volume sensing with a label-free approach, and is highly specific in identifying complementary (cDNA) from non-complementary (nDNA) sequences at room temperature. The detection limit of the current sensing scheme is demonstrated to be improvable via coupling to different sets of guided core modes by means of longitudinal offset in coupling light from the source to the fiber.
Keywords: Soft-glass
Microstructured fiber
Molecular beacon
DNA detection.
Description: Poster presentation
DOI: 10.1117/12.966847
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Appears in Collections:Aurora harvest 5
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