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Type: Journal article
Title: Seasonal variation in peritoneal dialysis-associated peritonitis: a multi-centre registry study
Author: Cho, Y.
Badva, S.
Hawley, C.
McDonald, S.
Brown, F.
Boudville, N.
Wiggins, K.
Bannister, K.
Clayton, P.
Johnson, D.
Citation: Nephrology Dialysis Transplantation, 2012; 27(5):2028-2036
Publisher: Oxford Univ Press
Issue Date: 2012
ISSN: 0931-0509
Statement of
Yeoungjee Cho, Sunil V. Badve, Carmel M. Hawley, Stephen P. McDonald, Fiona G. Brown, Neil Boudville, Kathryn J. Wiggins, Kym M. Bannister, Philip A. Clayton and David W. Johnson
Abstract: BACKGROUND: The role of seasonal variation in peritoneal dialysis (PD)-related peritonitis has been limited to a few small single-centre studies. METHODS: Using all 6610 Australian patients receiving PD between 1 October 2003 and 31 December 2008, we evaluated the influence of seasons on peritonitis rates (Poisson regression) and outcomes (multivariable logistic regression). RESULTS: The overall rate of peritonitis was 0.59 episodes per patient-year of treatment. Using winter as the reference season, the peritonitis incidence rate ratios (95% confidence interval) for summer, autumn and spring were 1.02(0.95–1.09), 1.01 (0.94–1.08) and 0.99 (0.92–1.06), respectively. Significant seasonal variations were observed in the rates of peritonitis caused by coagulase-negative Staphylococci (spring and summer peaks), corynebacteria (winter peak) and Gram-negative organisms (summer and autumn peaks). There were trends to seasonal variations in fungal peritonitis (summer and autumn peaks) and pseudomonas peritonitis (summer peak). No significant seasonal variations were observed for other organisms. Peritonitis outcomes did not significantly vary according to season. CONCLUSIONS: Seasonal variation has no appreciable influence on overall PD peritonitis rates or clinical outcomes. Nevertheless, significant seasonal variations were observed in the rates of peritonitis due to specific microorganisms, which may allow institutions to more precisely target infection control strategies prior to higher risk seasons.
Keywords: Humans
Gram-Negative Bacteria
Kidney Diseases
Anti-Bacterial Agents
Treatment Outcome
Peritoneal Dialysis
Retrospective Studies
Middle Aged
New Zealand
Rights: © The Author 2011. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.
DOI: 10.1093/ndt/gfr582
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