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|Title:||Synergistic effect of 14-alpha-lipoyl andrographolide and various antibiotics on the formation of biofilms and production of exopolysaccharide and pyocyanin by Pseudomonas aeruginosa|
|Citation:||Antimicrobial Agents and Chemotherapy, 2011; 55(6):3015-3017|
|Publisher:||Amer Soc Microbiology|
|Xiangping Zeng, Xiangyang Liu, Jiang Bian, Gang Pei, Huanqin Dai, Steven W. Polyak, Fuhang Song, Li Ma, Yuqiang Wang, and Lixin Zhang|
|Abstract:||Pseudomonas aeruginosa produces a biofilm that provides the bacteria with an effective barrier against antibiotics. Here, we investigated the synergy of various antibiotics with 14-alpha-lipoyl andrographolide (AL-1), focusing upon synthesis of the biofilm. AL-1 also inhibited the production of the exopolysaccharide and pyocyanin components. We propose that AL-1 may potentially serve as a cotherapy to combat P. aeruginosa.|
|Keywords:||Biofilms; Pseudomonas aeruginosa; Diterpenes; Pyocyanine; Polysaccharides, Bacterial; Anti-Bacterial Agents; Quorum Sensing|
|Rights:||Copyright © 2011, American Society for Microbiology. All Rights Reserved.|
|Appears in Collections:||Molecular and Biomedical Science publications|
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