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Type: Journal article
Title: Synergistic effect of 14-alpha-lipoyl andrographolide and various antibiotics on the formation of biofilms and production of exopolysaccharide and pyocyanin by Pseudomonas aeruginosa
Author: Zeng, X.
Liu, X.
Bian, J.
Pei, G.
Dai, H.
Polyak, S.
Song, F.
Ma, L.
Wang, Y.
Zhang, L.
Citation: Antimicrobial Agents and Chemotherapy, 2011; 55(6):3015-3017
Publisher: Amer Soc Microbiology
Issue Date: 2011
ISSN: 0066-4804
Statement of
Xiangping Zeng, Xiangyang Liu, Jiang Bian, Gang Pei, Huanqin Dai, Steven W. Polyak, Fuhang Song, Li Ma, Yuqiang Wang, and Lixin Zhang
Abstract: Pseudomonas aeruginosa produces a biofilm that provides the bacteria with an effective barrier against antibiotics. Here, we investigated the synergy of various antibiotics with 14-alpha-lipoyl andrographolide (AL-1), focusing upon synthesis of the biofilm. AL-1 also inhibited the production of the exopolysaccharide and pyocyanin components. We propose that AL-1 may potentially serve as a cotherapy to combat P. aeruginosa.
Keywords: Biofilms; Pseudomonas aeruginosa; Diterpenes; Pyocyanine; Polysaccharides, Bacterial; Anti-Bacterial Agents; Quorum Sensing
Rights: Copyright © 2011, American Society for Microbiology. All Rights Reserved.
RMID: 0020108751
DOI: 10.1128/AAC.00575-10
Appears in Collections:Molecular and Biomedical Science publications
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