Adelaide Research & Scholarship
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https://hdl.handle.net/2440/74884
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| Type: | Journal article |
| Title: | Enzyme activity assays within microstructured optical fibers enabled by automated alignment |
| Author: | Warren-Smith, S. Nie, G. Schartner, E. Salamonsen, L. Monro, T. |
| Citation: | Biomedical Optics Express, 2012; 3(12):1-10 |
| Publisher: | Optical Society of America |
| Issue Date: | 2012 |
| ISSN: | 2156-7085 2156-7085 |
| Statement of Responsibility: | Stephen C. Warren-Smith, Guiying Nie, Erik P. Schartner, Lois A. Salamonsen, and Tanya M. Monro |
| Abstract: | A fluorescence-based enzyme activity assay has been demonstrated within a small-core microstructured optical fiber (MOF) for the first time. To achieve this, a reflection-based automated alignment system has been developed, which uses feedback and piezoelectric actuators to maintain optical alignment. The auto-alignment system provides optical stability for the time required to perform an activity assay. The chosen assay is based on the enzyme proprotein convertase 5/6 (PC6) and has important applications in women's health. |
| Keywords: | (060.2370) Fiber optics sensors (060.4005) Microstructured fibers (280.1415) Biological sensing and sensors |
| Rights: | © 2012 OSA |
| DOI: | 10.1364/BOE.3.003304 |
| Appears in Collections: | Aurora harvest IPAS publications |
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