Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/74892
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Type: Journal article
Title: Continuous glucose monitoring and cognitive performance in type 2 diabetes
Author: Pearce, K.
Noakes, M.
Wilson, C.
Clifton, P.
Citation: Diabetes Technology & Therapeutics, 2012; 14(12):1-8
Publisher: Mary Ann Liebert, Inc Publishers
Issue Date: 2012
ISSN: 1520-9156
1557-8593
Statement of
Responsibility: 
Karma L. Pearce, Manny Noakes, Carlene Wilson, and Peter M. Clifton
Abstract: BACKGROUND: Type 2 diabetes is associated with reductions in cognitive function that are associated with glycated hemoglobin (HbA1c) levels, but there is no information on whether cognition is related to postmeal glucose spikes. We explored the relationship of cognition to glucose levels measured by a continuous glucose monitoring system (CGMS) both before and after a weight loss diet. SUBJECTS AND METHODS: Forty-four white subjects with type 2 diabetes (59.0±6.2 years old; body mass index, 32.8±4.2 kg/m2; HbA1c, 6.9±1.0%) completed an 8-week energy-restricted (approximately 6–7 MJ, 30% deficit) diet. Cognitive functioning (short-term memory, working memory, speed of processing [inspection time], psychomotor speed, and executive function) was assessed during four practice sessions, baseline, and Week 8. Parallel glucose levels were attained using the CGMS in 27 subjects. Outcomes were assessed by fasting blood glucose (FBG), postprandial peak glucose (Gmax), time spent >12 mmol/L (T>12), and 24-h area under the glucose curve (AUC24). RESULTS: Despite a fall in FBG of 0.65 mmol/L after 8 weeks, digits backward results correlated with FBG at both Week 0 and Week 8 (r=−0.43, P<0.01 and r=−0.32, P<0.01, respectively). Digits forward results correlated with FBG (r=−0.39, P<0.01), Gmax (r=−0.46, P<0.05), and AUC24 (r=−0.50, P<0.01) at Week 0 and FBG (r=−0.59, P<0.001), Gmax (r=0.37, P=0.01), AUC24 (r=−0.41, P<0.01), and percentage weight loss (r=0.31, P<0.01) at Week 8. Cognitive function was not altered by weight loss, gender, baseline lipid levels, or premorbid intelligence levels (National Adult Reading Test). CONCLUSIONS: FBG, Gmax, and AUC24 were related to cognitive function and an energy-restricted diet for 8 weeks did not alter this relationship.
Keywords: Humans; Diabetes Mellitus, Type 2; Dietary Carbohydrates; Blood Glucose; Blood Glucose Self-Monitoring; Monitoring, Physiologic; Body Mass Index; Diet, Reducing; Fasting; Analysis of Variance; Cognition; Glycemic Index; Postprandial Period; Adult; Aged; Middle Aged; Australia; Female; Male
Rights: © Mary Ann Liebert
RMID: 0020122618
DOI: 10.1089/dia.2012.0143
Appears in Collections:Medical Sciences publications

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