Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/75190
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Type: Journal article
Title: Role of microglia and toll-like receptor 4 in the pathophysiology of delirium
Author: Jalleh, R.
Koh, K.
Choi, B.
Liu, E.
Maddison, J.
Hutchinson, M.
Citation: Medical Hypotheses, 2012; 79(6):735-739
Publisher: Churchill Livingstone
Issue Date: 2012
ISSN: 0306-9877
1532-2777
Statement of
Responsibility: 
Ryan Jalleh, Keith Koh, Boyoun Choi, Ebony Liu, John Maddison, Mark R. Hutchinson
Abstract: Delirium is a serious medical condition that commonly afflicts elderly inpatients. This is especially common in the post-operative setting where it increases mortality, length of hospital stay and health care costs. The exact mechanisms involved in its pathogenesis remain uncertain and there is currently no effective pharmacological therapy for treatment or prevention of delirium. We hypothesize that microglia-mediated neuroinflammation via toll-like receptor 4 signalling is a significant contributor to post-operative delirium. Based on our proposed mechanism, three novel pharmacological therapies have been suggested to be effective to prevent or treat delirium. Curcumin, ibudilast and minocycline have been shown to interfere with various steps in the proinflammatory microglial activation intracellular signalling pathway, disrupting the subsequent neuroinflammatory cascade. We hypothesize that these drugs could be a novel pharmacotherapy that could significantly improve the outcome of post-operative delirious patients.
Keywords: Microglia; Humans; Delirium; Models, Theoretical; Aged; Middle Aged; Toll-Like Receptor 4
Rights: Copyright © 2012 Elsevier Ltd. All rights reserved.
RMID: 0020123182
DOI: 10.1016/j.mehy.2012.08.013
Grant ID: http://purl.org/au-research/grants/arc/DP110100297
Appears in Collections:Physiology publications

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