Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/76270
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Type: | Journal article |
Title: | Methylenetetrahydrofolate reductase gene variant (MTHFR C677T) and migraine: a case control study and meta-analysis |
Author: | Samaan, Z. Gaysina, D. Cohen-Woods, S. Craddock, N. Jones, L. Korszun, A. Owen, M. Mente, A. McGuffin, P. Farmer, A. |
Citation: | BMC Neurology, 2011; 11(1):66-1-66-9 |
Publisher: | BioMed Central Ltd. |
Issue Date: | 2011 |
ISSN: | 1471-2377 1471-2377 |
Statement of Responsibility: | Zainab Samaan, Daria Gaysina, Sarah Cohen-Woods, Nick Craddock, Lisa Jones, Ania Korszun, Mike Owen, Andrew Mente, Peter McGuffin and Anne Farmer |
Abstract: | Background: Migraine is a common disorder that often coexists with depression. While a functional polymorphism in methyleneterahydrofolate reductase gene (MTHFR C677T) has been implicated in depression; the evidence to support an association of MTHFR with migraine has been inconclusive. We aim to investigate the effect of this variant on propensity for migraine and to perform a systematic review and meta-analysis of studies of MTHFR and migraine to date. Methods: Individuals with migraine (n = 447) were selected from the Depression Case Control (DeCC) study to investigate the association between migraine and MTHFR C677T single nucleotide polymorphism (SNP) rs1801133 using an additive model compared to non-migraineurs adjusting for depression status. A meta-analysis was performed and included 15 studies of MTHFR and migraine. Results: MTHFR C677T polymorphism was associated with migraine with aura (MA) (OR 1.31, 95% CI 1.01-1.70, p = 0.039) that remained significant after adjusting for age, sex and depression status. A meta-analysis of 15 case-control studies showed that T allele homozygosity is significantly associated with MA (OR = 1.42; 95% CI, 1.10-1.82) and total migraine (OR = 1.37; 95% CI, 1.07-1.76), but not migraine without aura (OR = 1.16; 95% CI, 0.36-3.76). In studies of non-Caucasian population, the TT genotype was associated with total migraine (OR= 3.46; 95% CI, 1.22-9.82), whereas in studies of Caucasians this variant was associated with MA only (OR = 1.28; 95% CI, 1.002-1.63). Conclusions: MTHFR C677T is associated with MA in individuals selected for depression study. A meta-analysis of 15 studies supports this association and demonstrated effects across ethnic groups. |
Keywords: | Humans Genetic Predisposition to Disease Carbon-Nitrogen Ligases Logistic Models Case-Control Studies DNA Mutational Analysis Depression Psychiatric Status Rating Scales Gene Frequency Genotype Polymorphism, Single Nucleotide Adult Middle Aged Female Male Migraine with Aura Meta-Analysis as Topic |
Description: | Extent: 9p. |
Rights: | © 2011 Samaan et al; licensee BioMed Central Ltd.This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
DOI: | 10.1186/1471-2377-11-66 |
Published version: | http://dx.doi.org/10.1186/1471-2377-11-66 |
Appears in Collections: | Aurora harvest 4 Psychiatry publications |
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hdl_76270.pdf | Published version | 399.44 kB | Adobe PDF | View/Open |
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