Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/76514
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Risk factors for dialysis withdrawal: An analysis of the Australia and New Zealand Dialysis and Transplant (ANZDATA) Registry, 1999-2008 |
Author: | Chan, H. Clayton, P. McDonald, S. Agar, J. Jose, M. |
Citation: | Clinical Journal of the American Society of Nephrology, 2012; 7(5):775-781 |
Publisher: | American Society of Nephrology |
Issue Date: | 2012 |
ISSN: | 1555-9041 1555-905X |
Statement of Responsibility: | Hoi Wong Chan, Philip A. Clayton, Stephen P. McDonald, John W.M. Agar, Matthew D. Jose |
Abstract: | <h4>Background and objectives</h4>Dialysis withdrawal (DW) in patients with ESRD is increasing in importance. This study assessed causes of death and risk factors for DW in Australia and New Zealand in the first year of dialysis.<h4>Design, setting, participants, & measurements</h4>This retrospective observational cohort study included all adult Australians and New Zealanders beginning renal replacement therapy in 1999-2008.<h4>Results</h4>A total of 24,884 patients with 10,073 deaths were included. Deaths from cardiac and social causes (predominantly DW) accounted for 38% and 28% of all deaths, respectively. Cumulative incidence of DW was 3.5% at 1 year (95% confidence interval [CI], 3.3%-3.8%), 9.0% at 3 years (95% CI, 8.6%-9.4%), and 13.4% at 5 years (95% CI, 12.8%-13.9%). In multivariate analysis, predictors for DW in the first year were older age (subhazard ratio [SHR], 1.70 per decade [95% CI, 1.59-1.83]; P<0.001), late referral (SHR, 1.83 [95% CI, 1.59-2.11]; P<0.001), comorbid conditions (SHR, 1.33 per each additional comorbid condition [95% CI, 1.25-1.41]; P<0.001), and diabetes (SHR, 1.16 [95% CI, 1.00-1.34]; P=0.05). Negative predictors for DW included male sex (SHR, 0.75 [95% CI, 0.66-0.87]; P<0.001), indigenous ethnicity (SHR, 0.74 [95% CI, 0.58-0.95]; P=0.02), other nonwhite race (SHR, 0.66 [95% CI, 0.48-0.91]; P=0.01), and peritoneal dialysis user (SHR, 0.59 [95% CI, 0.49-0.72]; P<0.001).<h4>Conclusions</h4>DW is common among dialysis patients in Australia and New Zealand. Risk factors include older age, female sex, white race, diabetes, higher comorbidity burden, hemodialysis user, and late referral to nephrologist. |
Keywords: | Humans Kidney Failure, Chronic Heart Diseases Diabetes Mellitus Withholding Treatment Renal Dialysis Peritoneal Dialysis Registries Multivariate Analysis Retrospective Studies Age Factors Comorbidity Sex Factors Time Factors Adult Aged Aged, 80 and over Middle Aged Referral and Consultation Australia New Zealand Female Male Native Hawaiian or Other Pacific Islander Asian People White People |
Rights: | Copyright © 2012 by the American Society of Nephrology |
DOI: | 10.2215/CJN.07420711 |
Published version: | http://dx.doi.org/10.2215/cjn.07420711 |
Appears in Collections: | Aurora harvest 4 Public Health publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.