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Type: Journal article
Title: Matrix metalloproteinases: do they play a role in mucosal pahology of the oral cavity?
Author: Al-Azri, A.
Gibson, R.
Keefe, D.
Logan, R.
Citation: Oral Diseases, 2013; 19(4):347-359
Publisher: Blackwell Munksgaard
Issue Date: 2013
ISSN: 1354-523X
Statement of
A.R. Al-Azri, R.J. Gibson, D.M.K. Keefe and R.M. Logan
Abstract: Matrix metalloproteinases (MMPs) are critical factors in maintaining the integrity of mucosa and mediating normal biological processes. An imbalance between tissue levels of these mediators and their natural inhibitors is believed to underlie the pathophysiology of many diseases, including those affect the gastrointestinal and oral mucosae. The ongoing development of synthetic inhibitors of these mediators may provide opportunities to develop treatment modalities for patients suffering from these diseases. Understanding the role of MMPs in the pathophysiology of many diseases, however, is far from complete, and the improvement of pharmaceutical management strategies can only be achieved if the underlying process of these diseases is completely comprehended. This paper reviews the functions of matrix metalloproteinases and addresses their role in mediating mucosal pathologies with emphasis on oral mucosa.
Keywords: Matrix metalloproteinases
tissue inhibitors of metalloproteinases
oral disease
extracellular matrix
Rights: © 2012 John Wiley & Sons A/S
DOI: 10.1111/odi.12023
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