Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/77847
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Type: Journal article
Title: Major depression and first-time hospitalization with ischemic heart disease, cardiac procedures and mortality in the general population: a retrospective Danish population-based cohort study
Author: Gasse, C.
Laursen, T.
Baune, B.
Citation: European Journal of Cardiovascular Prevention and Rehabilitation, 2014; 21(5):532-540
Publisher: Sage Publications Ltd
Issue Date: 2014
ISSN: 2047-4873
2047-4881
Statement of
Responsibility: 
Christiane Gasse, Thomas M. Laursen and Bernhard T. Baune
Abstract: OBJECTIVE: We investigated the association between unipolar depression and incident hospital admissions due to ischemic heart disease, invasive cardiac procedures and mortality independent of other medical illnesses. METHODS: A population-based cohort of 4.6 million persons aged 15 years or older and born in Denmark was followed up from 1995–2009. Incidence rate ratio (IRR) and mortality rate ratio (MRR) were estimated by survival analysis, stratified by or adjusted for gender, age, severe chronic somatic comorbidity and calendar time. RESULTS: Adjusted risks of cardiac hospital admissions and death were significantly increased by up to 15% and 68%, respectively, in persons with hospital admissions due to depression, and were most increased in 15–59 year old women (IRR: 1.64; MRR: 2.57) and men with depression (IRR: 1.39; MRR: 2.21), and during the first 180 days after being diagnosed with depression (women: IRR: 1.38; MRR: 2.35; men: IRR: 1.42; MRR: 2.67). One-year mortality after new ischemic heart disease was elevated by 34% in women and men. By contrast, overall rates of invasive cardiac procedures following cardiac hospitalizations were significantly decreased by 34% in persons with depression but were twofold increased in men recently diagnosed with depression. CONCLUSION: Clinical depression leading to hospitalization was a risk factor for new cardiac complications independent of somatic comorbidity in the magnitude of other cardiac risk factors, particularly in individuals between 15–59 years of age and during the first weeks following psychiatric admission. Our findings support recent cardiovascular disease prevention guidelines on assessing depression among other psychosocial factors in patients at increased cardiovascular disease (CVD) risk.
Keywords: Ischemic heart disease
major depression
cardiac procedures
mortality
epidemiology
population-based
bi-directional association
Rights: © The European Society of Cardiology 2012
DOI: 10.1177/2047487312467874
Appears in Collections:Aurora harvest
Psychiatry publications

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