Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/79209
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Type: Journal article
Title: A transcription factor contributes to pathogenesis and virulence in streptococcus pneumoniae
Author: Mahdi, L.
Ebrahimie, E.
Adelson, D.
Paton, J.
Ogunniyi, A.
Citation: PLoS One, 2013; 8(8):1-9
Publisher: Public Library of Science
Issue Date: 2013
ISSN: 1932-6203
1932-6203
Statement of
Responsibility: 
Layla K. Mahdi, Esmaeil Ebrahimie, David L. Adelson, James C. Paton, Abiodun D. Ogunniyi
Abstract: To date, the role of transcription factors (TFs) in the progression of disease for many pathogens is yet to be studied in detail. This is probably due to transient, and generally low expression levels of TFs, which are the central components controlling the expression of many genes during the course of infection. However, a small change in the expression or specificity of a TF can radically alter gene expression. In this study, we combined a number of quality-based selection strategies including structural prediction of modulated genes, gene ontology and network analysis, to predict the regulatory mechanisms underlying pathogenesis of Streptococcus pneumoniae (the pneumococcus). We have identified two TFs (SP_0676 and SP_0927 [SmrC]) that might control tissue-specific gene expression during pneumococcal translocation from the nasopharynx to lungs, to blood and then to brain of mice. Targeted mutagenesis and mouse models of infection confirmed the role of SP_0927 in pathogenesis and virulence, and suggests that SP_0676 might be essential to pneumococcal viability. These findings provide fundamental new insights into virulence gene expression and regulation during pathogenesis.
Keywords: Animals
Mice
Streptococcus pneumoniae
Pneumococcal Infections
Bacterial Proteins
Transcription Factors
Gene Expression Profiling
Computational Biology
Virulence
Organ Specificity
Gene Expression Regulation, Bacterial
Mutation
Female
Gene Regulatory Networks
Host-Pathogen Interactions
Rights: © 2013 Mahdi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
DOI: 10.1371/journal.pone.0070862
Grant ID: http://purl.org/au-research/grants/nhmrc/565526
Published version: http://www.plosone.org/article/info:doi/10.1371/journal.pone.0070862
Appears in Collections:Aurora harvest
Environment Institute publications
Molecular and Biomedical Science publications

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