Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/80626
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dc.contributor.authorBright, F.en
dc.contributor.authorWinskog, C.en
dc.contributor.authorWalker, M.en
dc.contributor.authorByard, R.en
dc.date.issued2013en
dc.identifier.citationJournal of Forensic and Legal Medicine, 2013; 20(6):785-787en
dc.identifier.issn1752-928Xen
dc.identifier.issn1878-7487en
dc.identifier.urihttp://hdl.handle.net/2440/80626-
dc.description.abstractHypothermic fatalities in humans are characterized by a range of often subtle pathological findings that typically include superficial erosive gastritis (Wischnewski spots). Experimental studies have been successfully performed using animal models to replicate this finding, however study animals have inevitably been subjected to a variety of additional stressors including food deprivation, restraint and partial immersion in water while conscious. As it is recognised that stress on its own may cause superficial erosive gastritis, a model has been developed to enable the study of the effects of hypothermia in isolation. 42 Sprague-Dawley rats were allowed free social contact and were fed and watered ad libitum prior to being anaesthetized with isoflurane. Once unconscious, rats were placed on drape cloth covering metal mesh platforms in a styrofoam box packed with ice. The apparatus enabled both maintenance of a specific low temperature (26 °C) in 14 animals, and continued reduction of core temperatures in the remaining 28 (who all died of hypothermia under anaesthesia). Examination of the gastric mucosa in both groups macroscopically and microscopically failed to demonstrate typical Wischnewski spots in any of the 42 animals. Thus, in this model, death from hypothermia occurred without the development of these lesions. These results suggest that stress may be a significant effect modifier in the development of Wischnewski spots in lethal hypothermia.en
dc.description.statementofresponsibilityFiona Bright, Calle Winskog, Melissa Walker, Roger W. Byarden
dc.language.isoenen
dc.publisherChurchill Livingstoneen
dc.rightsCopyright © 2013 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.en
dc.subjectHypothermia; Stress; Wischnewski spots; Animal modelen
dc.titleWhy are Wischnewski spots not always present in lethal hypothermia? The results of testing a stress-reduced animal modelen
dc.typeJournal articleen
dc.identifier.rmid0020131447en
dc.identifier.doi10.1016/j.jflm.2013.05.003en
dc.identifier.pubid18224-
pubs.library.collectionPathology publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidBright, F. [0000-0002-1255-2350]en
dc.identifier.orcidByard, R. [0000-0002-0524-5942]en
Appears in Collections:Pathology publications

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