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Type: Journal article
Title: Systematic review of cytokines and growth factors for the management of oral mucositis in cancer patients
Author: Raber-Durlacher, J.
von Bultzingslowen, I.
Logan, R.
Bowen, J.
Al-Azri, A.
Everaus, H.
Gerber, E.
Gomez, J.
Pettersson, B.
Soga, Y.
Spijkervet, F.
Tissing, W.
Epstein, J.
Elad, S.
Lalla, R.
Citation: Supportive Care in Cancer, 2013; 21(1):343-355
Publisher: Springer-Verlag
Issue Date: 2013
ISSN: 0941-4355
Statement of
Judith E. Raber-Durlacher,Inger von Bültzingslöwen, Richard Martin Logan, Joanne Marie Bowen, Abdul Rahman Salim Al-Azri, Hele Everaus, Erich Gerber, Jesus Garcia Gomez, Bo G. Pettersson, Yoshihiko Soga, Fred K. L. Spijkervet, Wim J. E. Tissing, Joel Epstein, Sharon Elad, Rajesh V. Lalla
Abstract: Purpose: The aim of this project was to review the literature and define clinical practice guidelines for the use of cytokines and growth factor agents for the prevention or treatment of oral mucositis induced by cancer chemotherapy or radiotherapy. Methods: A systematic review was conducted by the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society for Oral Oncology (MASCC/ISOO). The body of evidence for each intervention, in each cancer treatment setting, was assigned an evidence level. Based on the evidence level, one of the following three guideline determinations was possible: Recommendation, Suggestion, No guideline possible. Results: Sixty-four clinical studies across 11 interventions were evaluated. A recommendation was made for the use of recombinant human KGF-1 (palifermin) at a dose of 60 μg/kg per day for 3 days prior to conditioning treatment and for 3 days post-transplant for prevention of oral mucositis in patients receiving high-dose chemotherapy and total body irradiation followed by autologous stem cell transplantation for hematological malignancies. A suggestion was made against using granulocyte macrophage colony-stimulating factor mouthwash for the prevention of oral mucositis in the setting of high-dose chemotherapy followed by autologous or allogeneic stem cell transplantation. No guideline was possible for any other cytokine or growth factor agents due to inconclusive evidence. Conclusions Of the cytokine and growth factor agents studied for oral mucositis, the evidence only supports use of palifermin in the specific population listed above. Additional well designed research is needed on other cytokine and growth factor interventions and in other cancer treatment settings.
Keywords: Mucositis
Growth factors
Systematic review
Rights: © Springer-Verlag 2012
DOI: 10.1007/s00520-012-1594-5
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Dentistry publications

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