Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/82080
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Type: | Journal article |
Title: | Comparative effects of prolonged and intermittent stimulation of the glucagon- like peptide 1 receptor on gastric emptying and glycemia |
Author: | Umapathysivam, M. Lee, M. Jones, K. Annink, C. Cousins, C. Trahair, L. Rayner, C. Chapman, M. Nauck, M. Horowitz, M. Deane, A. |
Citation: | Diabetes, 2014; 63(2):785-790 |
Publisher: | American Diabetes Association |
Issue Date: | 2014 |
ISSN: | 0012-1797 1939-327X |
Statement of Responsibility: | Mahesh M. Umapathysivam, Michael Y. Lee, Karen L. Jones,Christopher E. Annink, Caroline E. Cousins, Laurence G. Trahair, Chris K. Rayner, Marianne J. Chapman, Michael A. Nauck, Michael Horowitz, and Adam M. Deane |
Abstract: | Acute administration of glucagon-like peptide 1 (GLP-1) and its agonists slows gastric emptying, which represents the major mechanism underlying their attenuation of postprandial glycemic excursions. However, this effect may diminish during prolonged use. We compared the effects of prolonged and intermittent stimulation of the GLP-1 receptor on gastric emptying and glycemia. Ten healthy men received intravenous saline (placebo) or GLP-1 (0.8 pmol/kg $ min), as a continuous 24-h infusion (“prolonged”), two 4.5-h infusions separated by 20 h (“intermittent”), and a 4.5-h infusion (“acute”) in a randomized, double-blind, crossover fashion. Gastric emptying of a radiolabeled mashed potato meal was measured using scintigraphy. Acute GLP-1 markedly slowed gastric emptying. The magnitude of the slowing was attenuated with prolonged but maintained with intermittent infusions. GLP-1 potently diminished postprandial glycemia during acute and intermittent regimens. These observations suggest that short-acting GLP-1 agonists may be superior to long-acting agonists when aiming specifically to reduce postprandial glycemic excursions in the treatment of type 2 diabetes. |
Keywords: | Humans Insulin Glucose Blood Glucose Receptors, Glucagon Area Under Curve Cross-Over Studies Double-Blind Method Gastric Emptying Male Glucagon-Like Peptide 1 Young Adult Glucagon-Like Peptide-1 Receptor |
Rights: | © 2014 by the American Diabetes Association |
DOI: | 10.2337/db13-0893 |
Published version: | http://dx.doi.org/10.2337/db13-0893 |
Appears in Collections: | Anaesthesia and Intensive Care publications Aurora harvest 4 |
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hdl_82080.pdf | Published version | 870.79 kB | Adobe PDF | View/Open |
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