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https://hdl.handle.net/2440/82240
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Type: | Journal article |
Title: | Beneficial autoimmunity in type 1 diabetes mellitus |
Author: | Hauben, E. Roncarolo, M. Nevo, U. Schwartz, M. |
Citation: | Trends in Immunology, 2005; 26(5):248-253 |
Publisher: | Elsevier Sci Ltd |
Issue Date: | 2005 |
ISSN: | 1471-4906 1471-4981 |
Statement of Responsibility: | Ehud Hauben, Maria Grazia Roncarolo, Uri Nevo and Michal Schwartz |
Abstract: | The trigger that leads to the pathogenesis of type 1 diabetes is currently unknown. It is well established that the pathophysiology of the disease is biphasic. In the first stage, leukocytes infiltrate the pancreatic islets in a response that does not cause damage. In the second phase, which occurs only in diabetes-prone individuals and strains, autoreactive T cells acquire aggressive potential and destroy the majority of the pancreatic islets. Rodents and humans exhibit a physiological ripple of apoptotic beta-cell death shortly after birth, which induces an adaptive autoimmune response towards islet-antigens, both in diabetes-prone non-obese diabetic (NOD) mice and in mice that do not develop diabetes. Here, we propose that the early T cell-mediated autoimmune response towards islet-antigens is physiological, purposeful and beneficial. |
Keywords: | B-Lymphocytes T-Lymphocyte Subsets Animals Humans Diabetes Mellitus, Type 1 Apoptosis Cell Differentiation Autoimmunity Immune Tolerance Homeostasis |
Rights: | © 2005 Elsevier Ltd. All rights reserved. |
DOI: | 10.1016/j.it.2005.03.004 |
Published version: | http://dx.doi.org/10.1016/j.it.2005.03.004 |
Appears in Collections: | Aurora harvest Surgery publications |
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