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https://hdl.handle.net/2440/82724
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dc.contributor.author | Buxade, M. | - |
dc.contributor.author | Parra-Palau, J. | - |
dc.contributor.author | Proud, C. | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | Frontiers in Bioscience, 2008; 13(14):5359-5374 | - |
dc.identifier.issn | 1093-9946 | - |
dc.identifier.issn | 2768-6698 | - |
dc.identifier.uri | http://hdl.handle.net/2440/82724 | - |
dc.description.abstract | The human MAP kinase-interacting kinases (or MAP kinase signal-integrating kinases), Mnks, comprise a group of four proteins derived from two genes (Gene symbols: MKNK1 and MKNK2) by alternative splicing. Mnk1a/b differ at their C-termini, as do Mnk2a/2b: in each case, the a-form possesses a longer C-terminal region than the b-form, which lacks the MAP kinase-binding region. The N-termini of all forms contain a polybasic region which binds importin a and the translation factor scaffold protein eukaryotic initiation factor (eIF) 4G. The catalytic domains of Mnk1a/b and Mnk2a/b share three unusual features: two short inserts and a DFD feature where other kinases have DFG. Mnk isoforms differ markedly in their activity and regulation, and in subcellular localization. The best-characterised Mnk substrate is eIF4E. The cellular role of eIF4E phosphorylation remains unclear: it may promote export of certain mRNAs from the nucleus. Other Mnk substrates bind to AU-rich elements that modulate the stability/translation of specific mRNAs. Mnks may also control production of inflammatory mediators and signaling from tyrosine kinase receptors, as well as cell proliferation or survival. | - |
dc.description.statementofresponsibility | Maria Buxade, Josep L. Parra-Palau, Christopher G. Proud | - |
dc.language.iso | en | - |
dc.publisher | Frontiers in Bioscience Inc | - |
dc.rights | © Frontiers in Bioscience | - |
dc.source.uri | http://dx.doi.org/10.2741/3086 | - |
dc.subject | Mnk | - |
dc.subject | MAP Kinase | - |
dc.subject | Initiation Factor | - |
dc.subject | mRNA Translation | - |
dc.subject | Cytokine | - |
dc.subject | Apoptosis | - |
dc.subject | Review | - |
dc.title | The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases) | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.2741/3086 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Proud, C. [0000-0003-0704-6442] | - |
Appears in Collections: | Aurora harvest Molecular and Biomedical Science publications |
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