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Type: Journal article
Title: Interactions between adenosine and dopamine receptor antagonists with different selectivity profiles: effects on locomotor activity
Author: Collins-Praino, L.
Galtieri, D.
Collins, P.
Jones, S.
Port, R.
Paul, N.
Hockemeyer, J.
Muller, C.
Salamone, J.
Citation: Behavioural Brain Research, 2010; 211(25):148-155
Publisher: Elsevier Science BV
Issue Date: 2010
ISSN: 0166-4328
Statement of
Lyndsey E. Collins, Daniel J. Galtieri, Patricia Collins, Shawnet K. Jones, Russell G. Port, Nicholas E. Paul, Jörg Hockemeyer, Christa E. Müller, John D. Salamone
Abstract: Forebrain dopamine (DA) is a critical component of the brain circuitry regulating behavioral activation. Adenosine A(2A) antagonists reverse many of the behavioral effects of DA antagonists, and A(2A) receptors are co-localized with D(2) receptors on striatal medium spiny neurons. The present work was undertaken to determine if the ability of an A(2A) antagonist, a non-selective adenosine antagonist, or an A(1) antagonist to reverse the locomotor effects of DA blockade in rats differed depending upon whether D(1) or D(2) family receptors were being antagonized. The adenosine antagonists MSX-3, caffeine, DPCPX and CPT were studied for their ability to reverse the locomotor suppression induced by the D(1) antagonist SCH 39166 (ecopipam) and the D(2) antagonist eticlopride. The D(1) and D(2) antagonists suppressed locomotion in all experiments. The adenosine A(2A) receptor antagonist MSX-3 (0.5-2.0 mg/kg IP) significantly reversed the suppression of locomotion induced by eticlopride. The non-selective adenosine antagonist caffeine (5.0-20.0 mg/kg IP) also reversed the effect of eticlopride, though the effect was not as robust as that seen with MSX-3. The adenosine A(1) antagonists DPCPX (0.375-1.5 mg/kg) and CPT (3.0-12.0 mg/kg IP) were unable to reverse the locomotor impairment elicited by eticlopride. Furthermore, the attenuation of locomotion induced by the D(1) antagonist could only be reversed by the highest dose of MSX-3, but not by caffeine, DPCPX or CPT. DA and adenosine receptor antagonists interact in the regulation of locomotor activation, but the nature of this interaction appears to depend upon the receptor selectivity profiles of the specific drugs being tested.
Keywords: Prosencephalon; Animals; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Purinergic P1; Dopamine Antagonists; Analysis of Variance; Behavior, Animal; Motor Activity; Dose-Response Relationship, Drug; Drug Interactions; Male; Purinergic P1 Receptor Antagonists
Rights: © 2010 Elsevier B.V. All rights reserved.
RMID: 0020137269
DOI: 10.1016/j.bbr.2010.03.003
Appears in Collections:Anatomical Sciences publications

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