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https://hdl.handle.net/2440/85554
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dc.contributor.author | Ng, R. | - |
dc.contributor.author | Scott, N. | - |
dc.contributor.author | Strickland, D. | - |
dc.contributor.author | Gorman, S. | - |
dc.contributor.author | Grimbaldeston, M. | - |
dc.contributor.author | Norval, M. | - |
dc.contributor.author | Waithman, J. | - |
dc.contributor.author | Hart, P. | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Journal of Immunology, 2013; 190(11):5471-5484 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.issn | 1550-6606 | - |
dc.identifier.uri | http://hdl.handle.net/2440/85554 | - |
dc.description.abstract | Alterations to dendritic cell (DC) progenitors in the bone marrow (BM) may contribute to long-lasting systemic immunosuppression (>28 d) following exposure of the skin of mice to erythemal UV radiation (UVR). DCs differentiated in vitro from the BM of mice 3 d after UVR (8 kJ/m2) have a reduced capacity to initiate immunity (both skin and airways) when adoptively transferred into naive mice. Studies in IL-10−/− mice suggested that UV-induced IL-10 was not significantly involved. To investigate the immune capabilities of peripheral tissue DCs generated in vivo from the BM of UV-irradiated mice, chimeric mice were established. Sixteen weeks after reconstitution, contact hypersensitivity responses were significantly reduced in mice reconstituted with BM from UV-irradiated mice (UV-chimeric). When the dorsal skin of UV-chimeric mice was challenged with innate inflammatory agents, the hypertrophy induced in the draining lymph nodes was minimal and significantly less than that measured in control-chimeric mice challenged with the same inflammatory agent. When DCs were differentiated from the BM of UV-chimeric mice using FLT3 ligand or GM-CSF + IL-4, the cells maintained a reduced priming ability. The diminished responses in UV-chimeric mice were not due to different numerical or proportional reconstitution of BM or the hematopoietic cells in blood, lymph nodes, and skin. Erythemal UVR may imprint a long-lasting epigenetic effect on DC progenitors in the BM and alter the function of their terminally differentiated progeny. | - |
dc.description.statementofresponsibility | Royce L. X. Ng, Naomi M. Scott, Deborah H. Strickland, Shelley Gorman, Michele A. Grimbaldeston, Mary Norval, Jason Waithman and Prue H. Hart | - |
dc.language.iso | en | - |
dc.publisher | American Association of Immunologists | - |
dc.rights | © 2013 by The American Association of Immunologists, Inc. | - |
dc.source.uri | http://dx.doi.org/10.4049/jimmunol.1202786 | - |
dc.subject | Lymph Nodes | - |
dc.subject | Dendritic Cells | - |
dc.subject | T-Lymphocytes | - |
dc.subject | Bone Marrow Cells | - |
dc.subject | Animals | - |
dc.subject | Mice | - |
dc.subject | Dermatitis, Contact | - |
dc.subject | Hypertrophy | - |
dc.subject | Granulocyte-Macrophage Colony-Stimulating Factor | - |
dc.subject | Membrane Proteins | - |
dc.subject | Interleukin-4 | - |
dc.subject | Adoptive Transfer | - |
dc.subject | Bone Marrow Transplantation | - |
dc.subject | Ultraviolet Rays | - |
dc.subject | Cell Differentiation | - |
dc.subject | Cell Movement | - |
dc.subject | Graft Survival | - |
dc.subject | Chimerism | - |
dc.subject | Female | - |
dc.subject | Immunity, Innate | - |
dc.title | Altered immunity and dendritic cell activity in the periphery of mice after long-term engraftment with bone marrow from ultraviolet-irradiated mice | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.4049/jimmunol.1202786 | - |
dc.relation.grant | 1011203 | - |
dc.relation.grant | 539800 | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest 7 Molecular and Biomedical Science publications |
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